乳腺癌微钙化与预后因子的相关性分析

发布时间：2018-07-11 10:01

  本文选题：乳腺肿瘤 + 钼靶X线摄影　； 参考：《肿瘤》2017年11期

【摘要】：目的 :探讨乳腺癌微钙化征象与患者预后的相关性。方法 :将1 035例乳腺癌患者按术前钼靶X线摄影检查结果分成钙化组和无钙化组,分析钙化与肿瘤大小、腋窝淋巴结状态、组织学分级,分子分型以及雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人表皮生长因子受体2(human epidermal growth factor receptor-2,HER-2)之间的关系,评估微钙化对预后的影响。结果:腋窝淋巴结转移组患者的钙化率[53.6%(199/371)]高于无淋巴结转移组患者[47.1%(312/663)],HER-2阳性组患者的钙化率[63.3%(152/240)]高于阴性组患者[45.3%(360/795)],差异均有统计学意义(P值均0.05)。Luminal A型、Luminal B型、HER-2型和三阴型乳腺癌患者的钙化率分别为39.4%(41/104)、49.3%(239/485)、68.3%(84/12)和38.8%(80/206),差异有统计学意义(P0.05)。钙化组与无钙化组的生存差异无统计学意义(P0.05)。结论:乳腺癌钼靶X线摄影检查发现的钙化征象与HER-2表达、分子分型和腋窝淋巴结状态存在一定的相关性,钙化对乳腺患者的生存无明显影响。
[Abstract]:Objective: to investigate the correlation between microcalcification and prognosis of breast cancer. Methods: 1 035 patients with breast cancer were divided into calcified group and non calcified group according to the results of preoperative mammography. The size of tumor, axillary lymph node status and histological grade were analyzed. Molecular typing and the relationship between estrogen receptor ER, progesterone receptor PR and human epidermal growth factor receptor 2 (human epidermal growth factor receptor-2HER-2 were used to evaluate the effect of microcalcification on prognosis. Results: the calcification rate of patients with axillary lymph node metastasis [53.6% (199-371)] was higher than that of patients without lymph node metastasis [47.1% (312.1%)] HER-2 positive group [63.3% (152r240)] higher than that of negative group [45.3% (360-795)]. The difference was statistically significant (P = 0.05) .Luminal A Luminal B type HER-2 and Luminal A Luminal B type HER-2 and 鈪，

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