硫酸乙酰肝素成骨作用及成骨机制的研究进展
发布时间：2018-07-13 15:35
【摘要】：目的对硫酸乙酰肝素(heparan sulfate,HS)在骨形成和骨重建方面的作用进行讨论,综述其成骨机制的最新研究进展。方法查阅国内外有关HS体外作用于成骨细胞系、HS和HS复合支架材料作用于骨缺损动物模型以及HS蛋白聚糖影响骨骼发育的研究文献,并进行综合分析。结果 HS长链通过非共价结合方式和参与骨折愈合的生长因子结合,尤其是肝素结合性生长因子(如FGFs、BMP、TGF-β)等,保护这些生长因子免受蛋白酶降解,并可直接参与生长因子信号转导和骨细胞功能调节。HS调控成骨作用机制主要包括:刺激干细胞向成骨细胞分化、提高成骨细胞分化能力、促进骨基质形成、维持骨基质稳定和加速骨基质矿化。结论 HS的成骨作用显著,随着对其安全性的不断探索完善,HS可能成为临床治疗骨缺损延迟愈合和不愈合的有效手段,并有望为骨组织工程技术提供更多选择。
[Abstract]:Objective to discuss the role of heparan sulfate heparin (heparan sulfate) in bone formation and bone reconstruction, and to review the latest research progress of its osteogenic mechanism. Methods the domestic and foreign literatures about the effects of HS on osteoblast cell line HS and HS composite scaffold on bone defect animal model and the effect of HS proteoglycan on bone development were reviewed and analyzed. Results HS long chain could protect these growth factors from protease degradation by non-covalent binding with growth factors involved in fracture healing, especially heparin binding growth factors (such as FGFsPMP TGF- 尾). The mechanism of regulating osteogenesis mainly includes stimulating the differentiation of stem cells into osteoblasts, enhancing the differentiation ability of osteoblasts, and promoting the formation of bone matrix, which can directly participate in the signal transduction of growth factor and the regulation of osteocyte function. Maintain bone matrix stability and accelerate bone matrix mineralization. Conclusion HS plays a significant role in osteogenesis, and with the continuous exploration and improvement of its safety, HS may become an effective method for the treatment of delayed healing and nonunion of bone defects, and it is expected to provide more options for bone tissue engineering techniques.
【作者单位】： 南京医科大学附属无锡市人民医院骨科;江南大学药学院药用生物高分子研究室;
【基金】：国家自然科学基金面上项目(21574059)~~
【分类号】：R318.08;R68
本文编号：2119903
[Abstract]:Objective to discuss the role of heparan sulfate heparin (heparan sulfate) in bone formation and bone reconstruction, and to review the latest research progress of its osteogenic mechanism. Methods the domestic and foreign literatures about the effects of HS on osteoblast cell line HS and HS composite scaffold on bone defect animal model and the effect of HS proteoglycan on bone development were reviewed and analyzed. Results HS long chain could protect these growth factors from protease degradation by non-covalent binding with growth factors involved in fracture healing, especially heparin binding growth factors (such as FGFsPMP TGF- 尾). The mechanism of regulating osteogenesis mainly includes stimulating the differentiation of stem cells into osteoblasts, enhancing the differentiation ability of osteoblasts, and promoting the formation of bone matrix, which can directly participate in the signal transduction of growth factor and the regulation of osteocyte function. Maintain bone matrix stability and accelerate bone matrix mineralization. Conclusion HS plays a significant role in osteogenesis, and with the continuous exploration and improvement of its safety, HS may become an effective method for the treatment of delayed healing and nonunion of bone defects, and it is expected to provide more options for bone tissue engineering techniques.
【作者单位】： 南京医科大学附属无锡市人民医院骨科;江南大学药学院药用生物高分子研究室;
【基金】：国家自然科学基金面上项目(21574059)~~
【分类号】：R318.08;R68
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1 宋淑军;王宗烨;;硫酸乙酰肝素在骨折愈合中的作用[J];生命的化学;2008年04期
，本文编号：2119903
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