脊髓损伤后继发性损伤的相关信号通路
发布时间：2018-07-18 12:10
【摘要】：背景:在脊髓损伤的病理过程中,原发性损伤对脊髓神经结构的伤害难以逆转,目前国内外研究的重点主要集中在通过各种手段干预"继发性损伤"阶段,减少神经元的坏死和凋亡,减少损伤面积的进一步扩大,为轴突再生创造良好的微环境,阻断脊髓损伤后继发性损伤的进展并促进神经再生。目的:通过回顾分析国内外关于脊髓损伤后继发性损伤相关信号通路的研究报道,以明确参与脊髓损伤后继发损伤中的关键信号通路及药物作用途径,为脊髓损伤的治疗提供理论依据。方法:以"spinal cord injury,signaling pathway"为英文关键词,以"脊髓损伤,信号通路"为中文关键词,计算机检索Pub Med数据库、EMBASE数据库、Medline数据库、CNKI相关期刊论文及万方数据库2006至2016年有关脊髓损伤信号转导通路的文献,就脊髓损伤后继发性损伤相关信号通路进行综述。结果与结论:(1)目前脊髓损伤后继发性损伤相关信号转导通路主要集中在丝裂原活化蛋白激酶(MAPK)信号通路、核转录因子κB信号通路、PI3K/PKB(Akt)信号通路、Janus激酶/信号转导子和转录激活子(JAK/STAT)信号通路、Wnt信号通路方面;(2)以上通路在脊髓损伤后继发损伤的发生发展及修复中扮演重要角色,值得深入研究。
[Abstract]:Background: in the pathological process of spinal cord injury, it is difficult to reverse the injury of primary injury to spinal cord nerve structure. It can reduce the necrosis and apoptosis of neurons, reduce the further expansion of injury area, create a good microenvironment for axon regeneration, block the progress of secondary injury after spinal cord injury and promote nerve regeneration. Objective: to study the signal pathway related to secondary injury after spinal cord injury (sci) at home and abroad, so as to clarify the key signal pathway and drug pathway involved in the secondary injury after spinal cord injury (sci). To provide a theoretical basis for the treatment of spinal cord injury. Methods: "spinal cord injury-signaling pathway" was used as the key word in English and "spinal cord injury, signal pathway" as the Chinese keyword. To search the EMBASE database and Medline database of Pub Med database, CNKI full text database of Chinese periodicals and Wanfang database from 2006 to 2016 on signal transduction pathway of spinal cord injury were searched, and the signal pathways related to secondary injury after spinal cord injury were summarized. Results and conclusions: (1) at present, the signal transduction pathway related to secondary injury after spinal cord injury mainly focuses on mitogen-activated protein kinase (MAPK) signaling pathway. Nuclear transcription factor 魏 B signaling pathway PI3K / PKB (Akt) signaling pathway Janus kinase / signal transducers and activator of transcription (JAK / stat) signaling pathway Wnt signaling pathway; (2) the above pathway plays an important role in the development and repair of secondary injury after spinal cord injury. It is worth studying in depth.
【作者单位】： 北京中医药大学东直门医院;北京中日友好医院骨科;
【分类号】：R651.2
，
本文编号：2131861
[Abstract]:Background: in the pathological process of spinal cord injury, it is difficult to reverse the injury of primary injury to spinal cord nerve structure. It can reduce the necrosis and apoptosis of neurons, reduce the further expansion of injury area, create a good microenvironment for axon regeneration, block the progress of secondary injury after spinal cord injury and promote nerve regeneration. Objective: to study the signal pathway related to secondary injury after spinal cord injury (sci) at home and abroad, so as to clarify the key signal pathway and drug pathway involved in the secondary injury after spinal cord injury (sci). To provide a theoretical basis for the treatment of spinal cord injury. Methods: "spinal cord injury-signaling pathway" was used as the key word in English and "spinal cord injury, signal pathway" as the Chinese keyword. To search the EMBASE database and Medline database of Pub Med database, CNKI full text database of Chinese periodicals and Wanfang database from 2006 to 2016 on signal transduction pathway of spinal cord injury were searched, and the signal pathways related to secondary injury after spinal cord injury were summarized. Results and conclusions: (1) at present, the signal transduction pathway related to secondary injury after spinal cord injury mainly focuses on mitogen-activated protein kinase (MAPK) signaling pathway. Nuclear transcription factor 魏 B signaling pathway PI3K / PKB (Akt) signaling pathway Janus kinase / signal transducers and activator of transcription (JAK / stat) signaling pathway Wnt signaling pathway; (2) the above pathway plays an important role in the development and repair of secondary injury after spinal cord injury. It is worth studying in depth.
【作者单位】： 北京中医药大学东直门医院;北京中日友好医院骨科;
【分类号】：R651.2
，
本文编号：2131861
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