长骨炎症性肌纤维母细胞性肿瘤的临床病理观察

发布时间：2018-07-23 09:54

【摘要】：目的探讨骨内炎症性肌纤维母细胞性肿瘤(inflammatory myofibroblastic tumor,IMT)的临床病理特征、免疫表型、诊断及鉴别诊断。方法采用HE、免疫组化En Vision两步法染色对4例骨内IMT的临床病理学特征进行分析并复习相关文献。结果 4例IMT中女性1例,男性3例,发生于胫骨、股骨各2例,其中3例同时累及骨及软组织。组织学上由肌纤维母细胞样梭形细胞增生伴浆细胞、淋巴细胞、嗜酸性粒细胞等炎细胞浸润。免疫表型:vimentin、SMA、actin、H-caldesmon、CD34均呈阳性,部分细胞表达CD68。结论 IMT是具有局部侵袭性的交界性肿瘤,临床较罕见,应与一些良性及恶性的软组织肿瘤及肿瘤样病变鉴别。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of intraosseous inflammatory myofibroblastoma (inflammatory myofibroblastic tumorus). Methods the clinicopathological features of 4 cases of intraosseous IMT were analyzed by HEand en Vision two-step immunohistochemical staining and the relevant literatures were reviewed. Results of the 4 cases, 1 was female and 3 were male, which occurred in tibia and femur in 2 cases, 3 of which involved bone and soft tissue at the same time. Histologically, myofibroblast-like spindle cells proliferate with inflammatory cells such as plasma cells, lymphocytes, eosinophils, etc. The immunophenotype of SMAactinin H-caldesmonn was positive, and some of the cells expressed CD68. Conclusion IMT is a borderline tumor with local invasion, which is rare in clinic and should be distinguished from some benign and malignant soft tissue tumors and tumor-like lesions.
【作者单位】：北京积水潭医院病理科;北京积水潭医院骨肿瘤科;
【分类号】：R738

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