三黄汤灌注联合负压封闭引流技术治疗体表脓肿（溃破期）的临床研究
发布时间：2018-07-23 18:33
【摘要】：目的:观察三黄汤灌注联合负压封闭引流技术(VSD)对体表脓肿(溃破期)创面愈合的影响,并分析和探讨其可能的作用机理。方法:本研究采用前瞻性随机对照设计方案,选取2013年06月~2017年02月我科治疗且符合纳入标准的72例患者,采用随机数字表法随机分为3组,单纯中药组24例、单纯VSD组24例、联合组24例。单纯中药组仅采用三黄汤持续外敷,单纯VSD组仅采用生理盐水和VSD持续灌注冲洗,而联合组则采用三黄汤和VSD持续灌注冲洗。观察三组患者不同时间段创面创腔面积缩小率、创面肉芽生长情况、疼痛程度及炎性相关检查等指标。采用统计学方法分析比较三组患者的相应观察指标。结果:本研究患者均得到随访,无脱落或剔除现象。在创面创腔缩小情况方面,三组患者创面创腔面积缩小率均有所提高,差异具有统计学意义(P0.05),且联合组分别与单纯中药组和单纯VSD组的患者比较也存在差异(P0.05);在肉芽生长方面,三组患者创面评分均有所提高,差异具有统计学意义(P0.05),且联合组分别与单纯中药组和单纯VSD组的患者比较也存在差异(P0.05);在疼痛改善方面,三组术后第1d、5d、10d、15d的VAS改善均有统计学的差异(P0.05),术后10d、15d联合组分别与单纯中药组和单纯VSD组的患者VAS改善比较也存在差异(P0.05);在炎性反应的方面,第1d、3d、5d、10d和15d的WBC计数、CRP含量和ESR含量改善具有统计学的差异(P0.05),术后5d、10d、15d联合组分别与单纯中药组和单纯VSD组的炎性反应改善比较也存在差异(P0.05)。结论:三黄汤联合VSD用于促进创面愈合方面,其效果优于单纯应用三黄汤外敷或单纯VSD;三黄汤灌注与VSD技术创新性的有机结合治疗体表脓肿(溃破期)突出了传统中医外科治疗方法与现代医学临床技术进行有机结合的可行性,为外科体表脓肿(溃破期)的治疗提供一种新的操作简单、理论可行的治疗方法。
[Abstract]:Objective: to observe the effect of Sanhuang decoction perfusion combined with negative pressure blocking drainage (VSD) on wound healing of body surface abscess (ulceration), and to analyze its possible mechanism. Methods: a prospective randomized controlled design was used in this study. 72 patients who were treated by our department from June 2013 to February 2017 were randomly divided into three groups: Chinese medicine group (n = 24) and VSD group (n = 24). Combined group 24 cases. The traditional Chinese medicine group was only treated with Sanhuang decoction for external application, the simple VSD group was only irrigated with normal saline and VSD, while the combined group was irrigated with Sanhuang decoction and VSD. The reduction rate of wound cavity area, granulation growth, pain degree and inflammatory correlation examination were observed in three groups. Statistical method was used to analyze and compare the corresponding observation indexes of the three groups. Results: all the patients in this study were followed up. In the wound cavity reduction, the wound area reduction rate of the three groups increased, the difference was statistically significant (P0.05), and the combined group compared with the traditional Chinese medicine group and the simple VSD group patients were also different (P0.05); in the granulation growth, The wound score of the three groups were improved, the difference was statistically significant (P0.05), and there were differences between the combined group and the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in the improvement of VAS between the three groups on the 1st day, the 5th day, the 10th day and the 15th day after operation (P0.05). The improvement of VAS in the combined group was also different from that in the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in WBC content and ESR content between 10 and 15 days after operation (P0.05), and there was also significant difference in inflammatory response between the combined group and the traditional Chinese medicine group and the simple VSD group on the 5th day after operation (P0.05). Conclusion: Sanhuang decoction combined with VSD can promote wound healing. The effect is better than that of using Sanhuang decoction for external application or VSD alone, and the innovative combination of perfusion and VSD technology in the treatment of surface abscess (rupture stage) highlights the traditional Chinese medicine surgical treatment method and modern medical clinical technology in the treatment of body surface abscess. The feasibility of organic integration, To provide a new simple and theoretical method for the treatment of surgical surface abscess.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R632.5
本文编号：2140261
[Abstract]:Objective: to observe the effect of Sanhuang decoction perfusion combined with negative pressure blocking drainage (VSD) on wound healing of body surface abscess (ulceration), and to analyze its possible mechanism. Methods: a prospective randomized controlled design was used in this study. 72 patients who were treated by our department from June 2013 to February 2017 were randomly divided into three groups: Chinese medicine group (n = 24) and VSD group (n = 24). Combined group 24 cases. The traditional Chinese medicine group was only treated with Sanhuang decoction for external application, the simple VSD group was only irrigated with normal saline and VSD, while the combined group was irrigated with Sanhuang decoction and VSD. The reduction rate of wound cavity area, granulation growth, pain degree and inflammatory correlation examination were observed in three groups. Statistical method was used to analyze and compare the corresponding observation indexes of the three groups. Results: all the patients in this study were followed up. In the wound cavity reduction, the wound area reduction rate of the three groups increased, the difference was statistically significant (P0.05), and the combined group compared with the traditional Chinese medicine group and the simple VSD group patients were also different (P0.05); in the granulation growth, The wound score of the three groups were improved, the difference was statistically significant (P0.05), and there were differences between the combined group and the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in the improvement of VAS between the three groups on the 1st day, the 5th day, the 10th day and the 15th day after operation (P0.05). The improvement of VAS in the combined group was also different from that in the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in WBC content and ESR content between 10 and 15 days after operation (P0.05), and there was also significant difference in inflammatory response between the combined group and the traditional Chinese medicine group and the simple VSD group on the 5th day after operation (P0.05). Conclusion: Sanhuang decoction combined with VSD can promote wound healing. The effect is better than that of using Sanhuang decoction for external application or VSD alone, and the innovative combination of perfusion and VSD technology in the treatment of surface abscess (rupture stage) highlights the traditional Chinese medicine surgical treatment method and modern medical clinical technology in the treatment of body surface abscess. The feasibility of organic integration, To provide a new simple and theoretical method for the treatment of surgical surface abscess.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R632.5
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