辛伐他汀片联合五苓散用于心脏瓣膜置换术术后的临床研究

发布时间：2018-07-26 13:58

【摘要】：目的观察辛伐他汀片联合五苓散用于心脏瓣膜置换术术后的临床疗效及安全性。方法将100例进行心脏瓣膜置换术患者随机分为对照组50例和试验组50例。对照组于术前1周予以辛伐他汀片每次10 mg,bid,口服,术后第2天开始继续服用1周;试验组在对照组治疗的基础上,于术前1周予以五苓散每次6 g,tid,口服,术后第2天开始继续服用1周。比较2组患者的血流动力学指标、血脂指标,以及药物不良反应的发生情况。结果术后第3天,试验组和对照组的全血黏度高切分别为(6.06±0.26)和(7.70±0.42)m Pa·s,全血黏度低切分别为(10.31±0.35)和(12.30±0.38)m Pa·s,血浆黏度分别为(1.30±0.23)和(2.69±0.20)m Pa·s,血细胞比容分别为(46.59±1.20)%和(52.97±0.65)%,差异均有统计学意义(均P0.05)。术后1周,试验组和对照组的总胆固醇分别为(5.62±0.21)和(6.11±0.27)mmol·L-1,三酰甘油分别为(1.76±0.21)和(2.26±0.24)mmol·L-1,低密度脂蛋白胆固醇分别为(2.23±0.21)和(2.87±0.23)mmol·L-1,高密度脂蛋白胆固醇分别为(1.18±0.07)和(0.94±0.06)mmol·L-1,差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有腹痛、便秘和乏力,对照组的总药物不良反应主要有便秘和腹痛。试验组和对照组的总药物不良反应发生率分别为4.00%和6.00%,差异无统计学意义(P0.05)。结论辛伐他汀片联合五苓散用于心脏瓣膜置换术术后可显著改善患者的血流动力学和血脂,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of simvastatin tablets combined with Wuling Powder in cardiac valve replacement. Methods 100 patients undergoing cardiac valve replacement were randomly divided into control group (n = 50) and experimental group (n = 50). The control group was given simvastatin tablet 10 mg / time before operation for 1 week, then continued to take it for 1 week on the second day after operation, while the experimental group was given 6 g of Wuling powder each time for 6 g tid 1 week before operation on the basis of treatment in the control group. Continue taking it for 1 week on the second day after operation. Hemodynamic indexes, blood lipid indexes and adverse drug reactions were compared between the two groups. Results on the 3rd day after operation, the high shear rates of whole blood viscosity in the test group and the control group were (6.06 卤0.26) and (7.70 卤0.42) m Pa s,), respectively (10.31 卤0.35) and (12.30 卤0.38) m Pa s,), respectively (1.30 卤0.23) and (2.69 卤0.20) m Pa s, (46.59 卤1.20)% and (52.97 卤0.65), respectively (P0.05). 1 week after operation, the total cholesterol of the trial group and the control group were (5.62 卤0.21) and (6.11 卤0.27) mmol L-1, triglyceride were (1.76 卤0.21) and (2.26 卤0.24) mmol L -1, the low density lipoprotein cholesterol were (2.23 卤0.21) and (2.87 卤0.23) mmol L -1, the high density lipoprotein cholesterol were (1.18 卤0.07) and (0.94 卤0.06) mmol L -1, respectively (P0.05). The main adverse drug reactions in the test group were abdominal pain, constipation and fatigue, while the total adverse drug reactions in the control group were mainly constipation and abdominal pain. The incidence of total adverse drug reactions in the test group and the control group was 4.00% and 6.00%, respectively, with no significant difference (P0.05). Conclusion Simvastatin combined with Wuling Powder can significantly improve hemodynamics and blood lipids of patients after cardiac valve replacement and does not increase the incidence of adverse drug reactions.
【作者单位】：贵州工程职业学院医学院;淮安市第三人民医院中医科;贵阳中医学院第二附属医院妇产科;
【基金】：贵州省科学技术基金资助项目(C030304) 淮安市科技基金资助项目(2016BUMA0001)
【分类号】：R654.2

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