脾外伤患者自体脾片移植的多中心临床研究

发布时间：2018-07-28 15:25

【摘要】：目的探讨自体脾片移植术在脾外伤患者中的临床应用价值。方法收集脾外伤患者120例,其中自体脾片移植组72例,切脾组48例,比较两组手术时间、术中出血、术后住院天数、术后并发症发生率及术前和术后不同时期免疫指标的差异。结果自体脾片移植组手术时间长于切脾组(P0.05),术中出血、术后住院天数及术后并发症发生率与切脾组相比差异无统计学意义。术后1 d两组各免疫指标均较术前明显降低(P0.05)。术后1周两组各免疫指标均较术后1 d升高(P0.05)。术后3个月自体脾片移植组各免疫指标恢复至术前水平(P0.05),且各免疫指标均优于切脾组(P0.05)。结论脾切除能使机体免疫功能急剧下降,但机体免疫功能短期内可回升至一定水平,行自体脾片移植能使机体免疫功能恢复至术前水平。
[Abstract]:Objective to investigate the clinical value of autologous splenic graft in the patients with splenic trauma. Methods 120 cases of splenic trauma were collected, including 72 cases of splenic autograft group and 48 cases of splenectomy group, compared two groups of operation time, intraoperative bleeding, postoperative hospitalization days, postoperative complications and the difference of immune indexes before and after the operation. The operation time of the autologous splenic graft group was longer than that of the splenectomy group (P0.05). The intraoperative bleeding, postoperative hospital stay and the incidence of postoperative complications were not statistically significant compared with those in the splenectomy group. The immune indexes of the 1 D two groups after operation were significantly lower than those before the operation (P0.05). 1 weeks after the operation, the two groups were all higher than 1 d after operation (P0.05). 3 months postoperatively autologous The immune indexes of the splenic graft group were recovered to the preoperative level (P0.05), and all the immune indexes were superior to the splenectomy group (P0.05). Conclusion splenectomy can reduce the immune function sharply, but the immune function of the body can rise to a certain level in the short term, and the immune function of the body can be restored to the preoperative level by the autotransplantation of the spleen.
【作者单位】：深圳市宝安区人民医院普通外科;深圳市宝安区福永人民医院普通外科;深圳市宝安区中心医院普通外科;深圳市宝安区沙井人民医院普通外科;
【基金】：深圳市宝安区科技计划项目(编号:2013040)
【分类号】：R657.6

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