骨密度与老年髋部骨折三维有限元模型密度的相关性分析
发布时间：2018-08-03 14:26
【摘要】：目的：探讨骨密度与老年髋部骨折股骨近端三维有限元模型密度的关系,通过计算机mimics软件有限元建模,对不同年龄层次老年骨折病例的髋部骨密度变化进行分析,验证比对,探讨有效预判髋部骨折的部位类型和高危人群的方法和规律。方法：1.选取8例老年髋部骨折,60至90岁老年女患者,排除严重心肺疾病以及代谢性疾病,排除中风及小儿麻痹病史,其中4例股骨颈骨折,4例股骨转子间骨折；左侧肢体3例,右侧肢体5例。2.分别测定各例腰椎骨密度,并收集各例双侧髋关节的GE64排螺旋CT影像资料(以DICOM格式数据保存),运用Mimics 15.01软件在电脑对健侧股骨近端通过骨组织阈值分割、区域增长、腔隙填充、编辑蒙罩、三维重建功能、网格划分及材料赋值等步骤,自动生成的三维立体图像,并通过包裹、光滑等操作工具对模型进行光顺,构建生理特性接近健侧股骨近端的三维有限元模型,将建立的三维有限元模型导入abaqus软件,根据材料属性的模型以及经验公式,自动计算出该模型的最终可获得该模型密度。最后应用SPSS18.0软件对数据进行统计学分析,得出结论。成果：1.腰椎骨密度的平均值及方差分析：股骨颈骨折组的腰椎骨密度为(-3.15±0.54)g/cm2,股骨转子间骨折组的腰椎骨密度为(-4.05±0.24)g/cm2,两组骨密度差异具有统计学意义(t=3.046,P=0.02)。2.实验模型密度平均值及方差分析：股骨颈骨折组实验模型密度为(1.34±0.06)×106,股骨转子间骨折组的密度为(1.15±0.02)×106,两组实验模型密度差异具有统计学意义(t=6.0083,P=0.03)。3.骨密度仪测腰椎的BMD值与股骨实验模型密度值成线性正相关,r=0.881,P=0.004)。结论：1.通过Minics15.01的三维重建及Abaqus6.12的有限元分析,进行区域划分,控制网格的质量及数量,应用合理的材料赋值法,对模型区域分配的材料属性与股骨近端的真实属性相似,建立更加接近股骨近端生理解剖特点的三维有限元模型。2.根据统计结果,骨密度仪测腰椎的BMD值与股骨实验模型密度值成线性正相关,提示骨密度与老年髋部骨折股骨近端三维有限元模型密度成线性正相关的关系,可为进一步用有限元分析法探讨老年髋部骨折部位与骨密度的关系提供理论依据,预判髋部骨折高危人群的方法和规律。
[Abstract]:Objective: to investigate the relationship between bone mineral density (BMD) and the density of proximal femur in elderly patients with hip fracture. Objective: to study the methods and rules of predicting hip fracture site and high-risk population. Method 1: 1. Eight elderly women aged 60 to 90 years old with hip fracture were selected to exclude severe cardiopulmonary disease and metabolic disease, as well as a history of stroke and poliomyelitis, including 4 cases of femoral neck fracture and 4 cases of femoral intertrochanteric fracture, and 3 cases of left limb. Right extremity 5 cases. 2. Bone mineral density (BMD) of lumbar vertebrae was measured, and GE64 spiral CT images of bilateral hip joint were collected (stored in DICOM format). The bone tissue threshold was segmented by Mimics 15.01 software to segment the proximal end of the contralateral femur, and the area increased. Space filling, editing mask, 3D reconstruction function, mesh division and material assignment, etc., automatically generate 3D stereo image, and smooth the model by wrapping, smoothing and other operating tools. A three-dimensional finite element model with physiological characteristics close to the proximal end of the contralateral femur was constructed. The established three-dimensional finite element model was imported into abaqus software. According to the model of material properties and empirical formula, the final density of the model was calculated automatically. Finally, the statistical analysis of the data is made by SPSS18.0 software, and the conclusion is drawn. Result: 1. Analysis of variance of lumbar bone mineral density: the BMD of lumbar vertebrae was (-3.15 卤0.54) g / cm ~ (-2) in femoral neck fracture group and (-4.05 卤0.24) g / cm ~ (2) in femoral intertrochanteric fracture group. The average density of experimental model and the analysis of variance: the density of experimental model was (1.34 卤0.06) 脳 106 in femoral neck fracture group and (1.15 卤0.02) 脳 10 ~ (6) in femoral intertrochanteric fracture group. The BMD of lumbar vertebrae was positively correlated with the density of femur model by BMD. Conclusion 1. Through the 3D reconstruction of Minics15.01 and the finite element analysis of Abaqus6.12, the area is divided, the quality and quantity of the mesh are controlled, and the material attribute of the model area is similar to the real attribute of the proximal femur by using the reasonable material assignment method. A three-dimensional finite element model. 2. 2 was established, which is closer to the physiological and anatomical characteristics of proximal femur. According to the statistical results, the BMD of lumbar vertebrae measured by BMD was positively correlated with the density of femur experimental model, suggesting that BMD was positively correlated with the density of 3D finite element model of proximal femur of hip fracture in elderly patients. It can provide theoretical basis for further study on the relationship between hip fracture site and bone mineral density by finite element analysis, and predict the method and rule of high risk population of hip fracture.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R683
[Abstract]:Objective: to investigate the relationship between bone mineral density (BMD) and the density of proximal femur in elderly patients with hip fracture. Objective: to study the methods and rules of predicting hip fracture site and high-risk population. Method 1: 1. Eight elderly women aged 60 to 90 years old with hip fracture were selected to exclude severe cardiopulmonary disease and metabolic disease, as well as a history of stroke and poliomyelitis, including 4 cases of femoral neck fracture and 4 cases of femoral intertrochanteric fracture, and 3 cases of left limb. Right extremity 5 cases. 2. Bone mineral density (BMD) of lumbar vertebrae was measured, and GE64 spiral CT images of bilateral hip joint were collected (stored in DICOM format). The bone tissue threshold was segmented by Mimics 15.01 software to segment the proximal end of the contralateral femur, and the area increased. Space filling, editing mask, 3D reconstruction function, mesh division and material assignment, etc., automatically generate 3D stereo image, and smooth the model by wrapping, smoothing and other operating tools. A three-dimensional finite element model with physiological characteristics close to the proximal end of the contralateral femur was constructed. The established three-dimensional finite element model was imported into abaqus software. According to the model of material properties and empirical formula, the final density of the model was calculated automatically. Finally, the statistical analysis of the data is made by SPSS18.0 software, and the conclusion is drawn. Result: 1. Analysis of variance of lumbar bone mineral density: the BMD of lumbar vertebrae was (-3.15 卤0.54) g / cm ~ (-2) in femoral neck fracture group and (-4.05 卤0.24) g / cm ~ (2) in femoral intertrochanteric fracture group. The average density of experimental model and the analysis of variance: the density of experimental model was (1.34 卤0.06) 脳 106 in femoral neck fracture group and (1.15 卤0.02) 脳 10 ~ (6) in femoral intertrochanteric fracture group. The BMD of lumbar vertebrae was positively correlated with the density of femur model by BMD. Conclusion 1. Through the 3D reconstruction of Minics15.01 and the finite element analysis of Abaqus6.12, the area is divided, the quality and quantity of the mesh are controlled, and the material attribute of the model area is similar to the real attribute of the proximal femur by using the reasonable material assignment method. A three-dimensional finite element model. 2. 2 was established, which is closer to the physiological and anatomical characteristics of proximal femur. According to the statistical results, the BMD of lumbar vertebrae measured by BMD was positively correlated with the density of femur experimental model, suggesting that BMD was positively correlated with the density of 3D finite element model of proximal femur of hip fracture in elderly patients. It can provide theoretical basis for further study on the relationship between hip fracture site and bone mineral density by finite element analysis, and predict the method and rule of high risk population of hip fracture.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R683
【参考文献】
相关期刊论文 前10条
1 王之海;;手法复位配合中医药治疗股骨转子间骨折21例[J];广西中医药;2011年02期
2 刘少华;刘效仿;余海波;周观明;;外固定架治疗老年股骨粗隆间骨折[J];实用骨科杂志;2011年08期
3 裘世静;戴\戎;侯莜魁;王友;;老年股骨上段骨折的发病分布调查[J];上海医学;1991年07期
4 李宁华,区品中,朱汉民,杨定焯,赵晰,张大新,李恩,马翰章,邓力平,张韵,朱晓颖,安珍,刘力克,郑，
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