术前外周血中性粒细胞与淋巴细胞计数比鉴别甲状腺良恶性结节临床价值研究

发布时间：2018-08-03 17:20

【摘要】：目的分析术前外周血中性粒细胞与淋巴细胞计数比(NLR)在甲状腺良恶性结节鉴别诊断中的价值。方法回顾性分析2014-07-01—2015-06-30于中国人民解放军总医院普通外科经手术治疗的485例甲状腺结节病人的临床资料,根据术后常规病理学检查结果分为良性组和恶性组,对每组病例所对应的NLR进行对比分析,应用ROC曲线分析鉴别甲状腺良恶性结节的最佳cut-off值。结果甲状腺结节良性组和恶性组的NLR值分别为(1.6±0.5)和(1.9±1.0),恶性组有较高的中性粒细胞计数及较低的淋巴细胞计数,两组差异有统计学意义(P0.05)。由ROC曲线分析得出鉴别甲状腺结节良恶性的NLR最佳cut-off值为1.77,敏感度为65.8%,特异度为79.7%,AUC为0.723。结论术前外周血NLR值可指导甲状腺良恶性结节的鉴别诊断,高NLR值预示结节恶性。
[Abstract]:Objective to analyze the value of (NLR) in differential diagnosis of benign and malignant thyroid nodules. Methods the clinical data of 485 patients with thyroid nodule treated in general surgery department of Chinese people's Liberation Army General Hospital were retrospectively analyzed. The patients were divided into benign group and malignant group according to the results of postoperative routine pathological examination. The NLR of each group was compared and analyzed. The best cut-off value of ROC curve was used to distinguish benign and malignant thyroid nodules. Results the NLR values of benign and malignant thyroid nodule group were (1.6 卤0.5) and (1.9 卤1.0), respectively. The neutrophil count and lymphocyte count in malignant group were higher than those in malignant group (P0.05). According to ROC curve analysis, the best cut-off value of NLR for differentiating benign and malignant thyroid nodules was 1.77, the sensitivity was 65.8, the specificity was 79.7% and the specificity was 0.723. Conclusion preoperative NLR value of peripheral blood can guide the differential diagnosis of benign and malignant thyroid nodules, and high NLR value can predict the malignancy of thyroid nodules.
【作者单位】：中国人民解放军总医院普通外科;
【分类号】：R653

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