不同阿片类受体对盐酸氢考酮引起小鼠高活动性和镇痛过程的影响

发布时间：2018-08-04 21:11

【摘要】：目的探讨不同阿片类受体对盐酸氢考酮引起小鼠高活动性和镇痛过程的影响。方法采用小鼠自主活动测定和小鼠热板镇痛的实验方法研究μ、δ、κ3种阿片在盐酸氢考酮引起小鼠高活动性的不同作用。结果不同剂量的盐酸氢考酮均能够诱发小鼠的自发活动明显增加,且呈显著的量效关系(P0.05)。非选择性阿片受体拮抗剂能够剂量依赖性地降低盐酸氢考酮引起的小鼠自发活动增加(P0.05)。选择性μ受体拮抗剂对盐酸氢考酮引起的小鼠自发活动增加无影响,而选择性δ受体拮抗剂能够剂量依赖性地降低盐酸氢考酮引起的小鼠自发活动增加(P0.05)。选择性κ受体拮抗剂能够增强盐酸氢考酮引起的小鼠自发活动增加。选择性μ受体拮抗剂和选择性δ受体拮抗剂对小鼠无镇痛作用,而选择性κ受体拮抗剂能够拮抗盐酸氢考酮的镇痛作用。结论盐酸氢考酮引起的小鼠自发活动增加的作用可能通过δ受体介导,而其镇痛作用则可能是通过κ受体介导。
[Abstract]:Objective to investigate the effects of different opioid receptors on hyperactivity and analgesia induced by hydrocodone hydrochloride in mice. Methods the effects of 渭, 未 and 魏 on the hyperactivity induced by hydrocodone in mice were studied by the methods of spontaneous activity determination in mice and hot plate analgesia in mice. Results the spontaneous activity of mice induced by different doses of hydrocodone was significantly increased (P0.05). Non-selective opioid receptor antagonists could reduce the increase of spontaneous activity induced by hydrocodone hydrochloride in a dose-dependent manner (P0.05). Selective 渭 receptor antagonist had no effect on the increase of spontaneous activity induced by hydrocodone in mice, but selective 未 receptor antagonist could decrease the increase of spontaneous activity of mice induced by hydrocodone in a dose-dependent manner (P0.05). Selective 魏 receptor antagonists can enhance the spontaneous activity induced by hydrocodone hydrochloride in mice. Selective 渭 receptor antagonists and selective 未 receptor antagonists had no analgesic effect on mice, but selective 魏 receptor antagonists could antagonize the analgesic effect of hydrocodone hydrochloride. Conclusion the increase of spontaneous activity induced by hydrocodone hydrochloride in mice may be mediated by 未 receptor and its analgesic effect may be mediated by 魏 receptor.
【作者单位】： 安徽医科大学附属省立医院麻醉科;
【分类号】：R614
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