自体脂肪微片段治疗膝骨关节炎的临床研究

发布时间：2018-08-09 09:26

【摘要】：目的:通过自体脂肪微片段关节注射与玻璃酸钠关节注射两种不同方法治疗膝骨关节炎后的疗效进行对照观察,了解自体脂肪微片段治疗膝骨关节炎的疗效。方法:将满足纳入标准和排除标准的57名受试者随机分成两组。分别使用自体脂肪微片段和玻璃酸钠注射治疗膝骨关节炎。分别记录两组治疗前、治疗后1周、1个月、3个月及6个月的观察指标,进行数据整理,使用统计学方法进行数据分析后得出结论。结果:两组内在随访至治疗后3个月时治疗不同时间KOOS评分与前一次相比均有显著的差异(P0.05);但在治疗后6个月时,玻璃酸钠组较治疗后3个月无显著差异,而自体脂肪微片段仍有显著差异。玻璃酸钠组内在治疗后1周、治疗后1月VAS评分较前一次有显著差异(P0.05),且均值较前一次VAS评分小;在治疗后3月、治疗后6月分别与前一次VAS评分相比也有显著差异(P0.05),但均值较前一次VAS评分大。而在自体脂肪微片段组内只在随访6个月时与治疗后3个月相比较无显著差异。在两种治疗方法的比较中,治疗1周后,两组KOOS评分无显著差异(P0.05);VAS评分存在显著差异(P0.05)。在治疗1月后两组KOOS评分有显著差异(P0.05);VAS评分无显著差异(P0.05)。治疗3月及6月后两组KOOS评分均有显著差异(P0.05);VAS评分均有显著差异(P0.05)。治疗6个月后自体脂肪微片段组HSS优良率81.5%大于玻璃酸钠组HSS优良率73.3%。结论:与关节腔内玻璃酸钠注射相比行关节腔内自体脂肪微片段注射对缓解膝骨关节疼痛虽然起效较慢,但持续时间长且明显,而在改善膝关节功能方面效果也更显著。
[Abstract]:Objective: to observe the curative effect of autogenous fat microfragment injection and sodium hyaluronate injection on knee osteoarthritis and to understand the effect of autologous fat microfragment in the treatment of knee osteoarthritis. Methods: 57 subjects who met the inclusion criteria and exclusion criteria were randomly divided into two groups. Autogenous fat microfragments and sodium hyaluronate injection were used to treat knee osteoarthritis respectively. The observation indexes before treatment, 1 week, 1 month, 3 months and 6 months after treatment were recorded, and the data were sorted out. Results: there was significant difference in KOOS score between the two groups at different time after treatment from 3 months to 3 months after treatment (P0.05), but there was no significant difference in sodium hyaluronate group at 6 months after treatment as compared with 3 months after treatment. However, there were still significant differences in autologous fat microfragments. The VAS score of sodium hyaluronate group was significantly different from that of the previous group at 1 week after treatment (P0.05), and the mean value was lower than that of the previous VAS score. Six months after treatment, there were significant differences between the previous VAS score and the previous VAS score (P0.05), but the mean value was larger than the previous VAS score. However, there was no significant difference between autologous fat microfragment group and 3 months after treatment at 6 months follow-up. After one week of treatment, there was no significant difference in KOOS score between the two groups (P0.05). After one month of treatment, there was significant difference in KOOS score between the two groups (P0.05). There was no significant difference in VAS score between the two groups (P0.05). After 3 months and 6 months of treatment, there were significant differences in KOOS scores between the two groups (P0.05). After 6 months of treatment, the excellent and good rate of HSS in autologous fat microfragment group was 81.5%, that in sodium hyaluronate group was 73.3%, and that in sodium hyaluronate group was 73.3%. Conclusion: compared with intraarticular injection of sodium hyaluronate, intra-articular autogenous fat microinjection can alleviate the pain of knee joint more slowly, but it lasts for a long time, and it is more effective in improving the function of knee joint.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R684.3

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