雷奈酸锶结合钙剂对颈髓损伤合并骨质疏松症影响的临床研究

发布时间：2018-08-11 15:54

【摘要】：目的观察雷奈酸锶结合钙剂对颈髓损伤合并骨质疏松症的疼痛评分(VAS)、骨密度及骨代谢的影响。方法 2010年2月至2015年11月本科收治的颈髓损伤合并骨质疏松症患者80例,按随机数字表法将其分为治疗组(n=40)及对照组(n=40)。对照组给予钙剂治疗,治疗组给予雷奈酸锶联合钙剂进行治疗,共6个月。测定治疗不同时间段患者疼痛视觉模拟评分(VAS),腰椎及股骨颈骨密度(BMD)及1型前胶原N端前肽(P1NP)及1型胶原羧基端降解产物(β-CTX)的变化情况。结果治疗1个月、3个月及6个月后治疗组患者VAS评分显著低于对照组。治疗后6个月后,治疗组腰椎及股骨颈骨密度均显著高于对照组,比较差异有统计学意义(P0.05);β-CTX显著低于对照组,而P1NP显著高于对照组(P0.05),比较差异有统计学意义(P0.05)。结论雷奈酸锶联合钙剂可有效减轻颈髓损伤合并骨质疏松症患者的骨性疼痛程度,提升患者骨密度,改变骨代谢状态,值得临床推广。
[Abstract]:Objective to observe the effects of strontium ranilate combined with calcium on (VAS), bone mineral density and bone metabolism in patients with cervical spinal cord injury complicated with osteoporosis. Methods from February 2010 to November 2015, 80 patients with cervical spinal cord injury complicated with osteoporosis were randomly divided into treatment group (n = 40) and control group (n = 40). The control group was treated with calcium and the treatment group was treated with strontium rennionate combined with calcium for 6 months. The changes of (BMD), P1NP and 尾 -CTX of lumbar spine and femoral neck bone mineral density (BMD) of (VAS), and type 1 procollagen were measured. Results the VAS score in the treatment group was significantly lower than that in the control group after 1 month, 3 months and 6 months. Six months after treatment, the bone mineral density of lumbar vertebrae and femoral neck in the treatment group was significantly higher than that in the control group (P0.05), the difference was statistically significant (P0.05); 尾 -CTX was significantly lower than that in the control group, while P1NP was significantly higher than that in the control group (P0.05). Conclusion Strontium renniferate combined with calcium can effectively reduce the degree of bone pain in patients with cervical spinal cord injury and osteoporosis, improve bone density and change the state of bone metabolism, which is worthy of clinical promotion.
【作者单位】：郑州大学附属南阳市中心医院骨二科;
【分类号】：R580;R651.2

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