大隐静脉曲张与同型半胱氨酸的相关性研究

发布时间：2018-08-12 09:00

【摘要】：目的:研究大隐静脉曲张与同型半胱氨酸的相关性,同型半胱氨酸是否为大隐静脉曲张发病因素的独立危险性因子,为患大隐静脉曲张危险系数较高人群的血清学预防提供相关的理论指导与技术支持。方法:本实验收集了2015年7月—2016年11月期间在青海大学附属医院心胸血管外科住院治疗的58例患有大隐静脉曲张的患者,作为实验组(其中男性41人,女性17人)。另选择同期在青海大学附属医院体检的60例健康体检者,作为对照组(其中男性34人,女性26人)。将入选患者作为实验组(A),详细询问入选患者病史,并记录患者一般项目资料(年龄、性别等),于住院第2日清晨8时抽取患者4ml空腹血液送检,检测HCY、D-D、血脂四项等指标并做记录。将随机选取门诊健康体检者(严格按照纳入及排除标准纳入)作为对照组(B),记录受检者一般项目资料。于清晨8时抽取4ml空腹血送检,同样检测血HCY、D-D、血脂四项水平。所有检测结果均做详细记录。收集并整理数据资料,所有实验数据进行正态性检验,其中计量资料以X±s表示,两独立样本间单因素分析采用两独立样本t检验(检验水准定为α=0.05),Pα代表差异具有统计学意义。计数资料率的比较采用X2检验(检验水准定为α=0.05),Pα代表差异具有统计学意义。二分类变量的多个影响因素的相关性分析运用二元Logistic回归方法进行分析。根据统计学分析结果得出研究结论。结果:A组与B组在一般资料的对比结果显示:在年龄、性别方面两组无差异(p0.05)。A组与B组在血浆D-D水平对比结果显示:在血浆D-D水平方面两组无差异(p0.05)。A组与B组在血脂四项的对比结果显示:在血TC、TG、HDL-C水平方面两组无差异(p0.05)。在血LDL-C水平方面A组与B组存在差异(p0.05)。A组与B组在血Hcy水平对比结果显示:在血Hcy水平方面两组有差异(p0.05)。比较两组HHcy阳性率结果显示:A组的HHcy阳性率明显高于B组(p0.05)。Hcy及LDL与大隐静脉曲张相关性的二元Logistic回归结果显示:回归模型具有统计学意义(X2=29.432,p0.001),该回归模型的整体正确预测率为66.9%,结果得出Hcy及LDL的水平增高可能会增加大隐静脉曲张的患病风险。结论:1、大隐静脉曲张可能与HHcy存在相关性。2、大隐静脉曲张可能与LDL存在相关性。3、大隐静脉曲张可能与Hcy及LDL存在相关性,Hcy及LDL的水平增高可能会增加大隐静脉曲张的患病风险。4、Hcy可能为大隐静脉曲张的独立危险性因子。
[Abstract]:Objective: to study the relationship between varicose great saphenous vein and homocysteine, and whether homocysteine is an independent risk factor of great saphenous varices. To provide theoretical guidance and technical support for serological prevention of patients with varicose veins with high risk coefficient. Methods: from July 2015 to November 2016, 58 patients with varicose great saphenous vein (41 males and 17 females) who were hospitalized in Cardiothoracic Vascular surgery, affiliated Hospital of Qinghai University, were selected as experimental group. In addition, 60 healthy persons in Qinghai University affiliated Hospital were selected as control group (34 males and 26 females). The selected patients were selected as experimental group (A), to inquire about the history of the selected patients in detail, and to record the general items (age, sex, etc.) of the patients. At 8: 00 am on the 2nd day of hospitalization, the patients were sampled for 4ml fasting blood examination. HCYD-D and blood lipid were detected and recorded. The general item data of the subjects in the control group were recorded by (B), who were selected randomly (strictly according to the inclusion and exclusion criteria) as the control group. Fasting blood samples of 4ml were collected at 8: 00 am to detect four levels of serum HCYD-D-Dand blood lipids. All the test results were recorded in detail. The data were collected and sorted, and all experimental data were tested for normality. The measurement data were expressed as X 卤s, and the single factor analysis between the two independent samples was analyzed by two independent samples t test (the test level was 伪 -0.05) and P 伪 represented the difference was statistically significant. The rate of counting data was compared by X _ 2 test (the test level was 伪 -0.05) and P 伪 was statistically significant. The correlation analysis of several influencing factors of two classification variables is carried out by using binary Logistic regression method. According to the results of statistical analysis, the conclusion of the study is obtained. Results the comparison of general data between group A and group B showed that in age, There was no difference in plasma D-D level between group A and group B in terms of sex (p0.05). There was no difference in plasma D-D level between group A and group B (p0.05). There was no difference between group A and group B in blood lipid levels (p0.05). There was a significant difference between group A and group B in the level of LDL-C. The results of comparison between group A and group B showed that there was a difference in the level of serum Hcy between two groups (p0.05). The results of comparing the HHcy positive rate of two groups showed that the positive rate of HHcy in group A was significantly higher than that in group B (p0.05). Hcy and LDL were correlated with varicose vein of the great saphenous vein. The results showed that the regression model had statistical significance (X2O29.432p0.001), and the overall positive rate of the regression model was positive. The predicted rate was 66.9%. The results showed that the higher levels of Hcy and LDL might increase the risk of varicose varices of the great saphenous vein. Conclusion: 1, varicose great saphenous vein may be correlated with HHcy, varicose varices of great saphenous vein may be correlated with LDL, and varicose vein of great saphenous vein may be correlated with Hcy and LDL. The increase of Hcy and LDL may increase the varicose of great saphenous vein. Zhang's risk of Hcy may be an independent risk factor for varicose varices.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R654.4

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