高强度聚焦超声治疗肝包虫病的临床应用研究

发布时间：2018-08-19 17:11

【摘要】：目的分析高强度聚焦超声(high intensity focused ultrasound,HIFU)对肝包虫病的临床治疗效果和治疗过程的安全性,评估肝包虫病的HIFU治疗价值,指导临床工作治疗肝包虫病。方法回顾性分析2008～2010年重庆医科大学附二院院海扶中心明确诊断并经HIFU治疗的8例肝包虫患者的临床资料,比较手术前、后患者症状、影像学结果变化并追踪随访1年,了解肝包虫病的治疗结果及复发情况,评估HIFU对肝包虫的治疗效果；分析术后肝区疼痛、发热、术区皮肤损害等并发症并比较手术后患者肝功能指标变化情况,评估HIFU对肝包虫治疗的安全性。结果经HIFU治疗后所有患者临床症状明显改善,影像学上囊肿较前明显好转,术后患者肝功能损害在5天内基本恢复正常,其中有1例患者术中出现呕吐,术后未再发生呕吐症状,3例患者出现2-6天的持续性低热,6例患者出现2-7天的尚能忍受的肝区疼痛,3例患者出现皮肤肿胀,但所有并发症均在短期内恢复。术后1年的随访过程中除1例患者术后4月发现肝包虫复发,再次HIFU治疗好转外其余患者均未见肝包虫复发的症状及相应影像学变化。结论HIFU治疗肝包虫病安全有效,其具有手术创伤小,并发症少等特点,值得临床推广。
[Abstract]:Objective to evaluate the clinical efficacy and safety of high intensity focused ultrasound (high intensity focused) ultrasound in the treatment of hepatic hydatid disease, to evaluate the value of HIFU in the treatment of hepatic hydatid disease and to guide clinical work in the treatment of hepatic hydatid disease. Methods the clinical data of 8 patients with hepatic hydatid were analyzed retrospectively from 2008 to 2010 in Haifu Center, second Hospital of Chongqing Medical University and treated with HIFU. The symptoms and imaging results of the patients before and after operation were compared and followed up for 1 year. To understand the treatment and recurrence of hepatic hydatid disease, to evaluate the efficacy of HIFU in the treatment of hepatic hydatid disease, to analyze the complications of postoperative liver pain, fever, skin damage and so on, and to compare the changes of liver function indexes after operation. To evaluate the safety of HIFU in the treatment of hepatic hydatid. Results after HIFU treatment, all the patients' clinical symptoms were obviously improved, and the cysts were obviously improved in imaging. The damage of liver function returned to normal in 5 days after operation, and one patient had vomiting during the operation. There was no recurrence of vomiting symptoms in 3 patients with persistent low fever for 2 to 6 days. Skin swelling was found in 3 patients who were still able to bear pain in liver area for 2 to 7 days, but all the complications recovered in a short period of time. The recurrence of hepatic hydatid was found in one patient at 4 months after operation, and no symptoms and imaging changes of hepatic hydatid recurrence were found in other patients after 1 year of follow-up. Conclusion HIFU is safe and effective in the treatment of hepatic hydatid disease.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R657.3

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