小剂量右美托咪定对肾素-血管紧张素系统的影响

发布时间：2018-08-23 21:11

【摘要】：目的观察小剂量右美托咪定(Dex)对腹腔镜胆囊切除术患者肾素-血管紧张素系统的影响。方法选择本院40例行腹腔镜胆囊切除术患者,采用随机数字表分为对照组和Dex组,各20例。Dex 0.4μg/kg(Dex组)和等容量0.9%氯化钠溶液(对照组)在诱导开始时泵注,泵注时间约为10 min。同时所有患者采用相同的全身麻醉诱导和维持方案。于麻醉诱导前(T0)、切皮前(T1)、气腹后5 min(T2)、10 min(T3)、20 min(T4)、拔管后1min(T5)、5 min(T6)、10 min(T7)记录收缩压(SBP)、心率(HR);每组中有10例患者在T0、T2、T4、T5自非输液侧静脉留置针抽取静脉血3 ml,测定血浆肾素活性及血管紧张素Ⅱ水平;记录睁眼时间、拔管时间、术后疼痛视觉模拟评分(VAS);于T5~T7记录Ramsay评分。结果 Dex组T6、T7 SBP低于对照组(P0.05);Dex组VAS低于对照组(P0.05)。两组患者睁眼时间、拔管时间、Ramsay镇静评分比较,差异均无统计学意义(P0.05)。结论诱导时应用小剂量Dex可以维持围术期血流动力学平稳,不延长患者睁眼时间及拔管时间,可降低术后VAS。小剂量Dex(0.4μg/kg)对肾素-血管紧张素系统无显著影响。
[Abstract]:Objective to observe the effect of low dose dexmetidine (Dex) on renin-angiotensin system in patients undergoing laparoscopic cholecystectomy. Methods 40 patients undergoing laparoscopic cholecystectomy in our hospital were randomly divided into two groups: control group (n = 20) and Dex group (n = 20). Each of them was injected with 0.9% sodium chloride solution (Dex group) and 0.9% sodium chloride solution of equal volume at the beginning of induction. The time of injection was about 10 min.. At the same time, all patients were treated with the same general anesthesia induction and maintenance regimen. Before anesthesia induction (T 0), before skin incision (T 1), 5 min (T 2) after pneumoperitoneum (T 2) 10 min (T 3) 20 min (T 4), 1min (T 5) 5 min (T 6) 10 min (T 7) after extubation, systolic pressure (SBP), heart rate (HR); was recorded in 10 patients in each group. Angiotensin 鈪，

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