胰腺中段切除与胰腺体尾切除术式疗效的Meta分析
发布时间：2018-08-31 13:53
【摘要】：目的：系统评价胰腺中段切除术(CP)与胰腺体尾切除术(DP)的临床疗效。方法：应用计算机检索数据库：中国知网CNKI旗下的相关期刊论文(1988.1-2014.3)；美国国立医学图书馆(NLM)旗下的PubMed (1988.1～2014.3)、荷兰医学文摘数据库EMBASE (1988.1～2014.3)、美国国立医学图书馆MEDLINE (1988.1～2014.3)、美国科学引文索引SCI(1988.1～2014.3)和考克兰图书馆The Cochrane Library(1988.1-2014.3),对照试验中心注册数据库、学位论文数量库和重要会议论文数据库。对纳入的15篇临床对照试验使用RevMa5.2软件进行系统评价。结果：纳入CP组(436例),DP组(643例),共1079例。Meta分析显示,CP与DP相比,术后的胰瘘为38.3%(167/436)和24%(157/643),[OR：2.0,95%CI：1.48-2.71,0.01],CP组胰瘘发生率高,有统计学意义。术后并发症率为45.7%(164/359)和31.7%(152/480),[OR：1.52,95%CI：1.11-2.08,0.05]。CP组并发症发生率高,有统计学意义。内分泌功能不足为5.9%(13/220)和24%(39/159),(OR：0.21,95%CI：0.06～0.78,P0.05)CP内分泌发生率低,内分泌不足有统计学意义；外分泌功能不足为7.1%(22/280)和9.1%(33/362),(OR：0.49,95%CI：0.27～0.78,P0.05),CP外分泌发生率低,外分泌不足有统计学意义。手术时间显示两组差异有统计学意义[SMD：59.23,95%CI：22.41～96.05,P0.01]。住院时间显示两组差异有统计学意义[SMD：7.01,95%CI：1.94～12.09,0.01]。结论胰腺中段切除虽然早期并发症的发生率较高,但临床上是可以接受的,胰腺中段切除可能是保留胰腺内外分泌功能的合理手术方式。
[Abstract]:Objective: to evaluate the clinical effect of (CP) and (DP) in middle pancreatectomy. Methods: the full text database of Chinese periodicals (1988.1-2014.3) was searched by computer. PubMed (1988.1 / 2014.3), Netherlands Medical Abstract Database (EMBASE), MEDLINE (1988.1 / 2014.3), SCI (1988.1 / 2014.3) and The Cochrane Library (1988.1-2014.3, respectively. Academic dissertation database and important conference papers database. The 15 clinical controlled trials were systematically evaluated with RevMa5.2 software. Results: 1079 cases (1079 cases) were included in CP group. Meta-analysis showed that compared with DP, postoperative pancreatic fistula was 38.3% (167 / 436) and 24% (157 / 643). The incidence of pancreatic fistula in [OR:2.0,95%CI:1.48-2.71,0.01] CP group was higher than that in DP group. The rate of postoperative complications was 45.7% (164 / 359) and 31.7% (152 / 480) respectively. The incidence of complications in [OR:1.52,95%CI:1.11-2.08,0.05] .CP group was higher than that in control group (P < 0.05). The incidence of endocrine deficiency in CP was 5.9% (13 / 220) and 24% (39 / 159), (OR:0.21,95%CI:0.06~0.78,P0.05), and the incidence of endocrine deficiency was significantly lower than that in control group (7.1% (22 / 280) and 9.1% (33 / 362), (OR:0.49,95%CI:0.27~0.78,P0.05). The operative time was significantly different between the two groups [SMD:59.23,95%CI:22.41~96.05,P0.01]. The length of hospitalization was significantly different between the two groups [SMD:7.01,95%CI:1.94~12.09,0.01]. Conclusion although the incidence of early complications is high in the middle segment resection of pancreas, it is acceptable in clinic, and it may be a reasonable way to preserve the function of pancreatic exocrine and exocrine secretion.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R657.5
本文编号：2215192
[Abstract]:Objective: to evaluate the clinical effect of (CP) and (DP) in middle pancreatectomy. Methods: the full text database of Chinese periodicals (1988.1-2014.3) was searched by computer. PubMed (1988.1 / 2014.3), Netherlands Medical Abstract Database (EMBASE), MEDLINE (1988.1 / 2014.3), SCI (1988.1 / 2014.3) and The Cochrane Library (1988.1-2014.3, respectively. Academic dissertation database and important conference papers database. The 15 clinical controlled trials were systematically evaluated with RevMa5.2 software. Results: 1079 cases (1079 cases) were included in CP group. Meta-analysis showed that compared with DP, postoperative pancreatic fistula was 38.3% (167 / 436) and 24% (157 / 643). The incidence of pancreatic fistula in [OR:2.0,95%CI:1.48-2.71,0.01] CP group was higher than that in DP group. The rate of postoperative complications was 45.7% (164 / 359) and 31.7% (152 / 480) respectively. The incidence of complications in [OR:1.52,95%CI:1.11-2.08,0.05] .CP group was higher than that in control group (P < 0.05). The incidence of endocrine deficiency in CP was 5.9% (13 / 220) and 24% (39 / 159), (OR:0.21,95%CI:0.06~0.78,P0.05), and the incidence of endocrine deficiency was significantly lower than that in control group (7.1% (22 / 280) and 9.1% (33 / 362), (OR:0.49,95%CI:0.27~0.78,P0.05). The operative time was significantly different between the two groups [SMD:59.23,95%CI:22.41~96.05,P0.01]. The length of hospitalization was significantly different between the two groups [SMD:7.01,95%CI:1.94~12.09,0.01]. Conclusion although the incidence of early complications is high in the middle segment resection of pancreas, it is acceptable in clinic, and it may be a reasonable way to preserve the function of pancreatic exocrine and exocrine secretion.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R657.5
【参考文献】
相关期刊论文 前1条
1 万涛;陈明易;周晓东;张安红;贾伟;徐明月;冯玉泉;史宪杰;;中段胰腺切除术治疗胰腺体部肿瘤的初步经验[J];中国现代医学杂志;2013年14期
，本文编号：2215192
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