羟考酮联合右美托咪定在纤维支气管镜清醒气管插管中的应用

发布时间：2018-09-01 13:12

【摘要】：目的观察羟考酮复合右美托咪定在清醒气管插管中的镇痛镇静效果以及对呼吸和循环功能的影响。方法选择术前预计困难气道的择期手术患者40例,随机分为舒芬太尼组和羟考酮组。两组患者静脉泵注右美托咪定1μg/kg后以0.2μg·kg~(-1)·h~(-1)维持,舒芬太尼组静注舒芬太尼0.2μg/kg,羟考酮组静注羟考酮0.08mg/kg。监测患者用药及插管期间HR、MAP和SpO_2变化,并记录插管前Ramsay评分以及插管后PETCO_2和舒适度评分。结果两组患者用药及插管期间的血流动力学变化、镇静及舒适度差异无统计学意义。羟考酮组患者静注后SpO_2明显高于舒芬太尼组(P0.05),气管插管后PETCO_2明显降低(P0.05)。结论羟考酮复合右美托咪定可安全地用于清醒气管插管,镇痛、镇静效果良好,与舒芬太尼相比,呼吸抑制轻,不良反应少。
[Abstract]:Objective to observe the analgesic and sedative effects of hydroxycodone combined with dexmetidine on respiratory and circulatory function in conscious tracheal intubation. Methods 40 patients with difficult airway were randomly divided into sufentanil group and hydroxycodone group. After intravenous injection of dexmetidine (1 渭 g/kg), the patients in both groups were maintained with 0.2 渭 g kg~ (-1) h-1, sufentanil 0.2 渭 g / kg, hydroxycodone 0.08 mg / kg. The changes of HR,MAP and SpO_2 during medication and intubation were monitored and Ramsay scores before intubation and PETCO_2 and comfort scores after intubation were recorded. Results there was no significant difference in hemodynamics, sedation and comfort between the two groups during medication and intubation. The SpO_2 of hydroxycodone group was significantly higher than that of sufentanil group (P0.05), and the PETCO_2 was significantly decreased after endotracheal intubation (P0.05). Conclusion hydroxycodone combined with dexmetidine can be safely used in conscious tracheal intubation, analgesia and sedation. Compared with sufentanil, the respiratory inhibition is less and the adverse reactions are less.
【作者单位】：合肥市第二人民医院麻醉科;安徽省立医院麻醉科;
【分类号】：R614

【相似文献】