关节置换术后感染患者细胞因子与疼痛指标的变化观察

发布时间：2018-09-06 11:09

【摘要】：目的观察关节置换术后感染患者细胞因子与疼痛指标的变化情况,以为其上述指标的控制提供依据。方法选取2013年1月-2015年10月医院收治60例关节置换术后感染患者为观察组,同时期关节置换术后未发生感染60例患者为对照组,然后将两组细胞因子与疼痛指标血清水平进行比较,并比较观察组不同TKA分型患者的上述血清指标水平。结果观察组血清单核因子包括G-CSF、TNF-α、IL-6及IL-8水平分别(90.31±7.52)pg/ml、(1.56±0.24)ng/ml、(8.78±0.64)pg/ml及(10.20±1.14)pg/ml,均高于对照组(48.28±3.71)pg/ml、(0.98±0.11)ng/ml、(5.25±0.44)pg/ml及(6.10±0.53)pg/ml,同时观察组血清淋巴因子及疼痛指标均差于对照组,且不同TKA分型患者的上述细胞因子与疼痛指标血清水平也存在明显差异(P均0.05)。结论关节置换术后感染患者细胞因子与疼痛指标的血清表达水平波动较大,且不同TKA分型患者的表达水平也存在较大差异,应针对其这种变化给予针对性干预及控制。
[Abstract]:Objective to observe the changes of cytokines and pain indexes in infected patients after arthroplasty. Methods from January 2013 to October 2015, 60 patients with post-arthroplasty infection were selected as observation group and 60 patients without infection after arthroplasty in the same period as control group. Then the serum levels of cytokines and pain indexes were compared between the two groups and the serum levels of the patients with different TKA typing in the observation group. Results the levels of serum mononuclear factors including G-CSF- TNF- 伪 IL-6 and IL-8 in the observation group were (90.31 卤7.52) pg/ml, (1.56 卤0.24) ng/ml, (8.78 卤0.64) pg/ml and (10.20 卤1.14) pg/ml, respectively, which were significantly higher than those in the control group (48.28 卤3.71) pg/ml, (0.98 卤0.11) ng/ml, (5.25 卤0.44) pg/ml and (6.10 卤0.53) pg/ml,. The serum levels of these cytokines and pain indexes were significantly different in patients with different TKA classification (P < 0. 05). Conclusion the serum levels of cytokines and pain indexes fluctuate significantly after arthroplasty, and there are significant differences in the expression of cytokines in patients with different TKA types, so it is necessary to intervene and control these changes.
【作者单位】：郑州市第七人民医院关节外科;
【基金】：河南省科技攻关基金资助项目(132202811342)
【分类号】：R687.4

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