氨甲环酸对老年股骨粗隆间骨折患者行PFNA内固定手术围术期失血的有效性及安全性研究
发布时间：2018-09-10 08:29
【摘要】：目的评估术前静脉滴注氨甲环酸对老年股骨粗隆间骨折患者行股骨近端髓内钉-螺旋刀片(PFNA)手术围术期失血的影响。方法选择股骨粗隆间骨折行PFNA内固定的老年患者115例,分为治疗组(58例)和对照组(57例)。治疗组术前30min静脉滴注20mg/kg氨甲环酸,对照组无特殊处理。记录两组术前,术后第1、3天血红蛋白(Hb)及红细胞压积(Hct)情况,通过Gross方程与Nadler方程计算围术期总失血量,统计两组患者输血率、血栓性并发症发生情况。结果治疗组围术期总失血量(872.21±312.53)mL,对照组(1 162.41±368.64)mL,差异有统计学意义(P0.01)。治疗组输血率3.45%,对照组17.5%,差异有统计学意义(P0.01)。两组患者均无深静脉血栓及肺栓塞发生。治疗组肌间静脉血栓发生率5.1%,对照组7.0%,差异无统计学意义(P0.05)。结论老年股骨粗隆间骨折患者行PFNA内固定术前静脉滴注20mg/kg氨甲环酸能有效减少围术期失血,并且不增加血栓形成风险。
[Abstract]:Objective to evaluate the effect of intravenously instilled methoxycycline on perioperative blood loss in elderly patients with intertrochanteric fracture of femur treated with proximal femoral intramedullary nail and spiral blade (PFNA). Methods 115 elderly patients with intertrochanteric fracture treated with PFNA were divided into treatment group (58 cases) and control group (57 cases). 30min was intravenously infused with 20mg/kg in the treatment group and no special treatment was found in the control group. Hemoglobin (Hb) and hematocrit (Hct) were recorded 3 days before and 1 day after operation in both groups. The total blood loss was calculated by Gross equation and Nadler equation. The blood transfusion rate and thrombotic complications were calculated in both groups. Results the total blood loss in the treatment group (872.21 卤312.53) mL, control group (1 162.41 卤368.64) mL, was significantly different (P0.01). The blood transfusion rate was 3.45 in the treatment group and 17.5 in the control group, the difference was statistically significant (P 0.01). No deep venous thrombosis or pulmonary embolism occurred in both groups. The incidence of intramuscular venous thrombosis in the treatment group was 5.1 and that in the control group was 7.0. The difference was not statistically significant (P0.05). Conclusion intravenous infusion of 20mg/kg in elderly patients with intertrochanteric fracture of femur before PFNA fixation can effectively reduce perioperative blood loss and does not increase the risk of thrombosis.
【作者单位】： 重庆市涪陵中心医院骨科;
【分类号】：R687.3
[Abstract]:Objective to evaluate the effect of intravenously instilled methoxycycline on perioperative blood loss in elderly patients with intertrochanteric fracture of femur treated with proximal femoral intramedullary nail and spiral blade (PFNA). Methods 115 elderly patients with intertrochanteric fracture treated with PFNA were divided into treatment group (58 cases) and control group (57 cases). 30min was intravenously infused with 20mg/kg in the treatment group and no special treatment was found in the control group. Hemoglobin (Hb) and hematocrit (Hct) were recorded 3 days before and 1 day after operation in both groups. The total blood loss was calculated by Gross equation and Nadler equation. The blood transfusion rate and thrombotic complications were calculated in both groups. Results the total blood loss in the treatment group (872.21 卤312.53) mL, control group (1 162.41 卤368.64) mL, was significantly different (P0.01). The blood transfusion rate was 3.45 in the treatment group and 17.5 in the control group, the difference was statistically significant (P 0.01). No deep venous thrombosis or pulmonary embolism occurred in both groups. The incidence of intramuscular venous thrombosis in the treatment group was 5.1 and that in the control group was 7.0. The difference was not statistically significant (P0.05). Conclusion intravenous infusion of 20mg/kg in elderly patients with intertrochanteric fracture of femur before PFNA fixation can effectively reduce perioperative blood loss and does not increase the risk of thrombosis.
【作者单位】： 重庆市涪陵中心医院骨科;
【分类号】：R687.3
【相似文献】
相关期刊论文 前10条
1 任明明;韩振;李敬来;程颖;吴永前;;氨甲环酸对冠状动脉旁路移植术后出血疗效观察[J];中国当代医药;2010年19期
2 陈艰;氨甲环酸在体外循环心脏手术中的应用[J];江苏医药;1997年03期
3 赵e鹒，
本文编号：2233919
本文链接：https://www.wllwen.com/yixuelunwen/waikelunwen/2233919.html
最近更新
教材专著
