自体富血小板血浆在脊柱外科治疗中的应用

发布时间：2018-09-12 07:36

【摘要】：背景:自体富血小板血浆是来源自体、浓缩的血小板血浆。血小板经激活后能释放出大量高浓度的生长因子及生物活性物质,为其在诸多学科、领域的应用提供了理论依据;同时富血小板血浆源于自体,不会产生免疫反应,来源广泛、取材方便、费用低廉等特点使其日益受到研究人员及临床医师的青睐。目的:总结自体富血小板的制备方法及其性能,探讨其在脊柱外科各个方向的最新研究结果及作用机制。方法:应用计算机检索2000至2016年CNKI数据库及Pub Med数据库有关自体富血小板血浆应用于脊柱外科相关基础与临床研究的文献。对资料进行初审,按纳入和排除标准筛选后对其中42篇相关性强的文献进行进一步分析。结果与结论:①自体富血小板血浆由于富含多种生长因子及生物活性物质,在椎间盘修复、促进骨传导、骨诱导方面从基础到临床都有大量文献研究证实其有效性;②同时也有将自体富血小板血浆应用于结缔组织疾病引起的自发性脑脊液漏、和脊髓损伤长期卧床引起的压疮的韧带组织修复及皮肤再生成功的病案报道;③自体富血小板血浆在脊柱外科的应用展现出良好的发展前景。
[Abstract]:Background: autologous platelet-rich plasma is an autogenous, concentrated platelet plasma. After activation, platelets release a large amount of high concentrations of growth factors and bioactive substances, which provides a theoretical basis for their application in many disciplines and fields. Meanwhile, platelet-rich plasma is derived from autologous, does not produce immune response, and comes from a wide range of sources. It is more and more popular among researchers and clinicians because of its convenience and low cost. Objective: to summarize the preparation and performance of autologous platelets, and to explore the latest research results and mechanism of autologous platelets in all aspects of spinal surgery. Methods: CNKI database and Pub Med database from 2000 to 2016 were used to search the literatures about the application of autologous platelet-rich plasma in the basic and clinical study of spinal surgery. According to the inclusion and exclusion criteria, 42 articles were further analyzed. Results and conclusion autogenous platelet-rich plasma is rich in many kinds of growth factors and bioactive substances, and has been proved to be effective in intervertebral disc repair, bone conduction and bone induction. At the same time, there are also reports of the application of autologous platelet-rich plasma to spontaneous cerebrospinal fluid leakage caused by connective tissue disease, and to the successful repair of ligamentous tissue and skin regeneration due to long-term bed rest caused by spinal cord injury. 3 the application of autologous platelet-rich plasma in spinal surgery shows a good prospect.
【作者单位】：第二军医大学长征医院脊柱三科;解放军第187中心医院骨科;
【基金】：海南省自然科学基金(20168345) 海南省医药卫生科技项目(1440320.27A2004)~~
【分类号】：R687.3

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