钛合金假体表面涂层微孔孔径和孔隙率对骨整合的影响
发布时间：2018-09-12 10:06
【摘要】：目的探讨钛合金假体表面涂层微孔孔径和孔隙率对骨整合的影响。方法采用3D打印技术打印3种不同微孔孔径和孔隙率的钛合金假体,第一种假体表面微孔孔径(260.5±34.5)μm、孔隙率68.1%,第二种孔径(553.2±16.7)μm、孔隙率79.2%,第三种孔径(749.8±15.0)μm、孔隙率89.0%,分别标记为a、b、c型假体。选择新西兰大白兔27只,随机分为A、B、C组各9只,分别将a、b、c型假体植入兔股骨髓腔。术后4、8、12周,每组随机处死3只,通过Micro CT扫描观察各组成骨情况并测量骨体积分数(BV/TV)、组织矿物密度(TMD),通过拔出试验检测各组最大拔出力。结果术后4周,各组内植物均在位,微孔内及周围呈低信号,无明显沉积骨质;拔出标本仅远端有少量未成熟骨质,表面多覆盖纤维结缔组织及陈旧血凝块,处理标本时可轻易洗去;三组BV/TV、TMD及最大拔出力比较差异均无统计学意义(P均0.05)。术后8周,各组微孔内及周围均见部分中密度影,为未成熟骨质,A组相对较多;三组拔出标本远端均有明显骨质覆盖,A组假体体部表面可见沉积骨质;三组间BV/TV、TMD比较差异均无统计学意义(P均0.05),但A组最大拔出力明显高于B、C组(P均0.05)。术后12周,各组微孔内及周围均见高密度影,为沉积骨质,且伸入微孔内部,形成锁结,A组多于B、C组,无明显骨溶解;A组整个假体表面均匀覆盖较多骨质,B、C组远端和近端可见明显沉积骨质,但少于A组;A组BV/TV、TMD明显高于B、C组(P均0.05);最大拔出力A组B组C组,组间两两比较P均0.05。结论钛合金假体表面涂层微孔孔径226~295μm、孔隙率68.1%有利于促进骨整合,并具有较好的生物力学性能。
[Abstract]:Objective to investigate the effect of micropore diameter and porosity on bone integration on titanium alloy prosthesis. Methods three titanium alloy prostheses with different pore sizes and porosity were printed by 3D printing technique. The surface micropore size of the first prosthesis was (260.5 卤34.5) 渭 m, the porosity was 68.1 渭 m, the second pore size was (553.2 卤16.7) 渭 m, the porosity was 79.2 渭 m, the third pore size was (749.8 卤15.0) 渭 m, and the porosity was 89.0B. Twenty-seven New Zealand white rabbits were randomly divided into two groups: group A (n = 9) and group C (n = 9). Three rats were randomly killed in each group at 12 weeks after operation. Osteogenesis was observed and bone volume fraction (BV/TV) was measured by Micro CT scanning. Tissue mineral density (TMD),) was used to detect the maximal pull-out force of each group by pull-out test. Results at 4 weeks after operation, the plants in each group were in position with low signal intensity in and around the micropores, and there was no obvious deposition of bone, only a small amount of immature bone was located at the distal end of the pullout specimen, and the surface was covered with fibrous connective tissue and old blood clot. The BV/TV,TMD and maximal pull-out force of the three groups were not significantly different (P < 0. 05). At 8 weeks after operation, there were some middensity shadows in and around the micropores in each group, which were relatively more in group A than in group A, and there was obvious bone overlay on the surface of the prosthesis in group A, while in group A, the depositional bone could be seen on the surface of the prosthesis. There was no significant difference in BV/TV,TMD among the three groups (P 0.05), but the maximal pull-out force of group A was significantly higher than that of group C (P 0.05). At 12 weeks after operation, there were high density shadows in and around the micropores in each group, which were deposited bone, and extended into the micropore. The formation of locked junctions in group A was more than that in group B (C). In group A, the surface of the whole prosthesis was evenly covered with more bony bone, but the BV/TV,TMD of group A was significantly higher than that of group A (P 0.05), and the maximal pull-out force was higher in group B (P 0.05) than that in group A (P < 0.05), but there was a significant difference between the two groups (P < 0.05), but the BV/TV,TMD of group A was significantly higher than that of group A (P < 0.05), while that of group A was significantly higher than that of group B (P < 0.05). Conclusion the micropore diameter of titanium alloy prosthesis coating is 226 ~ 295 渭 m, and the porosity of 68.1% is helpful to promote bone integration and has good biomechanical properties.
【作者单位】： 上海长征医院;
【基金】：上海市教育委员会科研创新项目(15ZZ039)
【分类号】：R687.3
，
本文编号：2238679
[Abstract]:Objective to investigate the effect of micropore diameter and porosity on bone integration on titanium alloy prosthesis. Methods three titanium alloy prostheses with different pore sizes and porosity were printed by 3D printing technique. The surface micropore size of the first prosthesis was (260.5 卤34.5) 渭 m, the porosity was 68.1 渭 m, the second pore size was (553.2 卤16.7) 渭 m, the porosity was 79.2 渭 m, the third pore size was (749.8 卤15.0) 渭 m, and the porosity was 89.0B. Twenty-seven New Zealand white rabbits were randomly divided into two groups: group A (n = 9) and group C (n = 9). Three rats were randomly killed in each group at 12 weeks after operation. Osteogenesis was observed and bone volume fraction (BV/TV) was measured by Micro CT scanning. Tissue mineral density (TMD),) was used to detect the maximal pull-out force of each group by pull-out test. Results at 4 weeks after operation, the plants in each group were in position with low signal intensity in and around the micropores, and there was no obvious deposition of bone, only a small amount of immature bone was located at the distal end of the pullout specimen, and the surface was covered with fibrous connective tissue and old blood clot. The BV/TV,TMD and maximal pull-out force of the three groups were not significantly different (P < 0. 05). At 8 weeks after operation, there were some middensity shadows in and around the micropores in each group, which were relatively more in group A than in group A, and there was obvious bone overlay on the surface of the prosthesis in group A, while in group A, the depositional bone could be seen on the surface of the prosthesis. There was no significant difference in BV/TV,TMD among the three groups (P 0.05), but the maximal pull-out force of group A was significantly higher than that of group C (P 0.05). At 12 weeks after operation, there were high density shadows in and around the micropores in each group, which were deposited bone, and extended into the micropore. The formation of locked junctions in group A was more than that in group B (C). In group A, the surface of the whole prosthesis was evenly covered with more bony bone, but the BV/TV,TMD of group A was significantly higher than that of group A (P 0.05), and the maximal pull-out force was higher in group B (P 0.05) than that in group A (P < 0.05), but there was a significant difference between the two groups (P < 0.05), but the BV/TV,TMD of group A was significantly higher than that of group A (P < 0.05), while that of group A was significantly higher than that of group B (P < 0.05). Conclusion the micropore diameter of titanium alloy prosthesis coating is 226 ~ 295 渭 m, and the porosity of 68.1% is helpful to promote bone integration and has good biomechanical properties.
【作者单位】： 上海长征医院;
【基金】：上海市教育委员会科研创新项目(15ZZ039)
【分类号】：R687.3
，
本文编号：2238679
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