右美托咪定联合喷他佐辛对老年患者全髋关节置换术后的镇痛效果及炎症因子、Fib和D-二聚体水平的影响
发布时间：2018-09-18 21:39
【摘要】：目的:探讨右美托咪定联合喷他佐辛对老年患者全髋关节置换术后的镇痛效果及其对炎症因子、纤维蛋白原(Fib)和D-二聚体水平的影响。方法:选取96例符合纳入标准的老年全髋关节置换术患者作为观察对象,按照随机数字表法分为对照组和观察组,各48例。对照组给予喷他佐辛镇痛治疗,观察组在对照组的基础上给予右美托咪定镇痛。术后采用视觉模拟评分(VAS)法评价疼痛程度。分别比较两组患者术后6、12、24 h时的VAS。术后24 h比较两组患者血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)等炎症因子水平及Fib、D-二聚体水平,并比较两组不良反应发生情况。结果:与对照组相比,观察组患者术后6、12、24 h时VAS降低[分别为(2.35±0.94)vs.(3.96±1.05)分,(1.66±0.71)vs.(2.87±0.82)分,(1.32±0.52)vs.(2.15±0.63)分],差异均有统计学意义(P0.05)。术后24 h与对照组比较,观察组血清TNF-α、IL-6、IL-8等炎症因子水平降低[分别为(2.02±0.67)vs.(3.95±0.96)pg·ml~(-1),(32.24±4.76)vs.(40.16±5.25)pg·ml~(-1),(20.37±4.26)vs.(30.29±5.71)pg·ml~(-1)],Fib、D-二聚体水平也降低[分别为(3.9±0.3)vs.(4.2±0.4)g·L~(-1),(224.7±18.5)vs.(251.3±20.2)ng·ml~(-1)],两组间比较差异均有统计学意义(P0.05)。术后对照组和观察组不良反应发生率分别为8.3%和14.6%,两组间比较差异无统计学意义(P0.05),所有患者均未出现严重不良反应。结论:右美托咪定联合喷他佐辛在老年患者全髋关节置换术后镇痛中应用效果良好,能够有效减轻术后疼痛及炎症反应,改善血液高凝状态,且不良反应轻微。
[Abstract]:Aim: to investigate the analgesic effect of dexmetomidine combined with pentazol on the levels of inflammatory factors, fibrinogen (Fib) and D-dimer in elderly patients after total hip replacement. Methods: 96 elderly patients with total hip replacement were selected and divided into control group and observation group according to random digital table. The control group was treated with pantazosine analgesia, and the observation group was treated with dexmetomidine on the basis of the control group. Postoperative pain was evaluated by visual analogue score (VAS). Comparison of VAS. between the two groups at 612h after operation Serum levels of tumor necrosis factor 伪 (TNF- 伪), interleukin-6 (IL-6), interleukin-8 (IL-8) and Fib,D- dimer were compared 24 hours after operation between the two groups. Results: compared with the control group, the VAS of the observation group was significantly lower than that of the control group at 612h (2.35 卤0.94) vs. (3.96 卤1.05), (1.66 卤0.71) vs. (2.87 卤0.82) and (1.32 卤0.52) vs. (2.15 卤0.63), respectively (P0.05). 鏈悗24 h涓庡鐓х粍姣旇緝,瑙傚療缁勮娓匱NF-伪,IL-6,IL-8绛夌値鐥囧洜瀛愭按骞抽檷浣嶽鍒嗗埆涓，
本文编号：2249163
[Abstract]:Aim: to investigate the analgesic effect of dexmetomidine combined with pentazol on the levels of inflammatory factors, fibrinogen (Fib) and D-dimer in elderly patients after total hip replacement. Methods: 96 elderly patients with total hip replacement were selected and divided into control group and observation group according to random digital table. The control group was treated with pantazosine analgesia, and the observation group was treated with dexmetomidine on the basis of the control group. Postoperative pain was evaluated by visual analogue score (VAS). Comparison of VAS. between the two groups at 612h after operation Serum levels of tumor necrosis factor 伪 (TNF- 伪), interleukin-6 (IL-6), interleukin-8 (IL-8) and Fib,D- dimer were compared 24 hours after operation between the two groups. Results: compared with the control group, the VAS of the observation group was significantly lower than that of the control group at 612h (2.35 卤0.94) vs. (3.96 卤1.05), (1.66 卤0.71) vs. (2.87 卤0.82) and (1.32 卤0.52) vs. (2.15 卤0.63), respectively (P0.05). 鏈悗24 h涓庡鐓х粍姣旇緝,瑙傚療缁勮娓匱NF-伪,IL-6,IL-8绛夌値鐥囧洜瀛愭按骞抽檷浣嶽鍒嗗埆涓，
本文编号：2249163
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