胆石症发病情况及影响因素

发布时间：2018-10-05 15:45

【摘要】：目的研究胆石症疾病的发病率及其影响因素。方法以首次参加2006～2007年度健康体检的101510例开滦在职及退休职工作为研究对象开展随访调查,观察胆石症的发病情况。对研究对象进行统一问卷调查、血液生化和腹部超声检查。最终纳入统计分析的有82341例。用Kaplan-Meier法计算胆石症的发病率,并用log-rank检验比较不同性别、年龄人群胆石症发病率的差异。采用Cox比例风险模型分析影响胆石症的因素。结果1平均随访5.52±1.40年,在82341例研究对象中,随访期间腹部超声检查共检出新发胆石症1846例,其胆石症累积发病率为2.2%。其中男性1434例,女性412例,其胆石症累积发病率分别为2.2%、2.3%。2采用多变量Cox比例风险回归模型分析胆石症发病影响因素,结果显示与胆石症发病相关的危险因素有年龄(40-60岁比40岁,HR=1.95[95%CI 1.63～2.33],≥60岁比40岁,HR=3.34[95%CI 2.75～4.06])、BMI(24-28kg/m2比24kg/m2,HR=1.33[95%CI1.19～1.49],≥28kg/m2比24kg/m2,HR=1.49[95%CI 1.30～1.71])、糖尿病(是比理想空腹血糖,HR=1.17[95%CI 1.01～1.36])、hs CRP(0.80-2.10mg/L比0.30mg/L,HR=1.22[95%CI 1.06～1.42],≥2.10mg/L比0.30mg/L,HR=1.48[95%CI 1.28～1.70]),保护因素有饮酒(是比否,HR=0.87[95%CI 0.77～0.99])。结论胆石症的发病率均随着年龄、血压、BMI、空腹血糖的增长而增高。增龄、高BMI、糖尿病、高hs CRP属于胆石症发病的相关危险性因素,适量饮酒属于胆石症发病的相关保护性因素。
[Abstract]:Objective to study the incidence of cholelithiasis and its influencing factors. Methods 101510 active and retired workers of Kailuan who first participated in the physical examination in 2006 and 2007 were followed up and the incidence of cholelithiasis was observed. The subjects were investigated by uniform questionnaire, blood biochemistry and abdominal ultrasound. Finally, 82341 cases were included in the statistical analysis. Kaplan-Meier method was used to calculate the incidence of cholelithiasis and log-rank test was used to compare the incidence of cholelithiasis among different genders and age groups. Cox proportional risk model was used to analyze the factors affecting cholelithiasis. Results (1) the mean follow-up was 5.52 卤1.40 years. During the follow-up period, 1846 cases of new cholelithiasis were detected by abdominal ultrasonography, and the cumulative incidence of cholelithiasis was 2.2%. There were 1434 males and 412 females. The cumulative incidence of cholelithiasis was 2.2 and 2.3 respectively. Multivariate Cox proportional risk regression model was used to analyze the influencing factors of cholelithiasis. 缁撴灉鏄剧ず涓庤儐鐭崇棁鍙戠梾鐩稿叧鐨勫嵄闄╁洜绱犳湁骞撮緞(40-60宀佹瘮40宀，

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