乳腺导管内癌伴微浸润患者术后行CEF与CTF方案化疗的效果比较

发布时间：2018-10-10 19:18

【摘要】：目的对比观察乳腺导管内癌伴微浸润患者术后行CEF方案与CTF方案化疗的效果。方法将96例经手术组织病理检查证实为乳腺导管内癌伴微浸润患者随机分为观察组和对照组各48例,均行乳腺癌改良根治术治疗,术后分别给予CEF方案与CTF方案化疗;两组均以3周为1个周期,共化疗6个周期。记录两组化疗期间药物不良反应,并随访5年以统计两组5年无病生存期及生存率。结果观察组无病生存期为(50.7±6.2)个月、5年生存率为45.8%,对照组分别为(48.7±7.3)个月、41.7%,两组比较差异无统计学意义。观察组血液系统、心脏及皮肤黏膜损伤发生率分别为20.8%、25.0%、12.5%,低于对照组的58.3%、56.3%、41.7%(P均0.05);两组生殖、消化、神经系统不良反应发生率比较,差异无统计学意义(P均0.05)。结论乳腺导管内癌伴微浸润患者术后行CEF与CTF方案化疗的远期效果无明显差别,但CEF方案不良反应少。
[Abstract]:Objective to compare the effect of CEF regimen and CTF regimen on breast intraductal carcinoma with microinvasion. Methods Ninety-six patients with intraductal carcinoma with microinvasion were randomly divided into two groups: the observation group (n = 48) and the control group (n = 48). All patients were treated with modified radical mastectomy. The patients were treated with CEF regimen and CTF regimen respectively. The two groups were treated with 3 weeks as one cycle and 6 cycles of chemotherapy. Adverse drug reactions during chemotherapy were recorded and followed up for 5 years. Results the disease-free survival time was (50.7 卤6.2) months and the 5-year survival rate was (45.8) months in the observation group and (48.7 卤7.3) months in the control group. There was no significant difference between the two groups. The incidence of blood system, heart and skin and mucous membrane injury in the observation group was 20.8%, 25.0 and 12.5%, respectively, which was lower than that in the control group (58.3%) (P 0.05), but there was no significant difference between the two groups in the incidence of adverse reactions of reproduction, digestion and nervous system (P 0.05). Conclusion there is no significant difference between CEF and CTF regimen chemotherapy in patients with intraductal breast cancer with microinvasion after operation, but the adverse reaction of CEF regimen is less.
【作者单位】：桂林医学院附属医院;桂林医学院;
【分类号】：R737.9

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