右美托咪定与布托啡诺对老年经尿道前列腺电切患者术中及术后寒战的影响

发布时间：2018-10-15 16:06

【摘要】：目的探讨右美托咪定与布托啡诺对老年经尿道前列腺电切术(TURP)患者术中及术后寒战的影响。方法行TURP前列腺增生术中或术后发生寒战患者82例,采用随机数字法分为右美托咪定组(42例)和布托啡诺组(40例),右美托咪定组在寒战时给予0.5μg/kg右美托咪定静脉泵注,布托啡诺组在寒战时给予0.01 mg/kg布托啡诺静脉泵注;检测并记录给药前(T1)、给药3 min(T2)、5 min(T3)、10 min(T4)、20 min(T5)、30 min(T6)时两组平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(Sp O2)、呼吸频率(RR),评价两种药物治疗寒战的效果。结果右美托咪定组HR、MAP水平在T2~T6时刻均显著低于布托啡诺组(P0.05),右美托咪定组RR在T2、T3时刻均显著低于布托啡诺组(P0.05),其他时刻无差异(P0.05);两组SpO_2各个时点均无统计学差异(P0.05);两组术中或术后寒战发生情况无统计学差异(P0.05),且两种药物在治疗寒战上的疗效无统计学差异(P0.05);给药后两组均无严重不良反应发生。结论右美托咪定与布托啡诺治疗行TURP术中或术后出现寒战均具有较高的疗效,但右美托咪定在维持患者血流动力学上具有更明显的优势。
[Abstract]:Objective to investigate the effect of dexmetomidine and butorphanol on shivering during and after transurethral resection of prostate (TURP). Methods 82 patients with shivering during or after operation of TURP prostatic hyperplasia were randomly divided into two groups: dexmetomidine group (n = 42) and butorinol group (n = 40). Dexmetomidine group was given 0.5 渭 g/kg dexmetomidine intravenously during shivering. In butorphanol group, butorphanol was injected intravenously at 0. 01 mg/kg during shivering. The mean arterial pressure (MAP), (HR), pulse oxygen saturation (Sp O 2) and respiratory rate (RR),) were measured and recorded before administration (T1), 3 min (T2), 5 min (T3), 10 min (T4), 20 min (T5), 30 min (T6). Results the HR,MAP level of dexmetomidine group was significantly lower than that of butorphinol group at T2~T6 time (P0.05), and the RR level of dexmetomidine group was significantly lower than that of butorphanol group at T2T 3 moment (P0.05), and there was no significant difference in SpO_2 between the two groups at each time point (P0.05). (P0.05); there was no significant difference between the two groups in the incidence of shivering during or after operation (P0.05), and there was no significant difference in the curative effect of the two drugs in the treatment of shivering (P0.05); there were no serious adverse reactions in the two groups after administration. Conclusion Dentomidine and butorphenol are effective in the treatment of shivering during or after TURP, but dexmetomidine is more effective in maintaining hemodynamics.
【作者单位】：长治医学院附属和济医院麻醉科;长治医学院附属和济医院普外科;
【分类号】：R614

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