点阵激光联合复方倍他米松注射液治疗增生性瘢痕20例疗效观察

发布时间：2018-10-31 14:10

【摘要】：目的评价CO_2点阵激光联合复方倍他米松注射液局部注射治疗增生性瘢痕的疗效及不良反应。方法选择60例温哥华烧伤瘢痕评分(VSS)总分为7~12分的增生性瘢痕患者为受试者,随机分成3组,各20例,分别接受CO_2点点阵激光联合复方倍他米松注射液局部注射(治疗组),CO_2点点阵激光单一疗法(对照1组)及复方倍他米松注射液局部注射单一疗法(对照2组)。于每次治疗后1个月及疗程(4次治疗)结束后半年随访,参照VSS对受试者进行综合评分,并评估有效率。记录不良反应发生情况。结果所有三组受试者VSS评分治疗后均较治疗前有一定改善,差异有统计学意义(P0.05)。组间改善情况差异有统计学意义(P0.05)。三组均有部分患者术后出现色素沉着、皮肤萎缩及毛囊炎等局部不良反应,可自行缓解,未发生严重的不良反应。结论 CO_2点点阵激光及复方倍他米松注射液对增生性瘢痕均有一定的疗效,且两者联合治疗的效果最佳。整个治疗过程无严重不良事件,安全可靠。
[Abstract]:Objective to evaluate the efficacy and side effects of CO_2 lattice laser combined with local injection of compound betamethasone injection in the treatment of hypertrophic scar. Methods 60 hypertrophic scar patients with (VSS) score of 7 ~ 12 in Vancouver burn scar were randomly divided into 3 groups, 20 cases in each group. CO_2 dot array laser combined with local injection of compound betamethasone injection (treatment group), CO_2 dot array laser monotherapy (control group 1) and local injection of compound betamethasone injection (control group 2). The subjects were followed up 1 month after each treatment and 6 months after the course of treatment (4 treatments). The subjects were evaluated with VSS and the effective rate was evaluated. Adverse reactions were recorded. Results the VSS scores of all three groups were improved after treatment, and the difference was statistically significant (P0.05). There was significant difference in improvement between groups (P0.05). In all the three groups, pigmentation, skin atrophy and folliculitis were found in some patients. Conclusion CO_2 dot array laser and compound betamethasone injection have certain curative effect on hypertrophic scar, and the combination of them is the best. There were no serious adverse events in the whole treatment process and it was safe and reliable.
【作者单位】：中国人民解放军第59中心医院烧伤整形外科;昆明医科大学附属第二医院整形科;
【分类号】：R622

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