切开挂线联合甲硝唑与左氧氟沙星对肛周脓肿感染患者病原菌及血浆内毒素水平的影响

发布时间：2018-11-04 13:32

【摘要】：目的分析切开挂线联合甲硝唑、左氧氟沙星对肛周脓肿感染患者血浆内毒素水平及病原菌的影响。方法选择2015年9月-2016年9月期间医院收治的肛周脓肿感染患者70例,按照随机、对照、双盲试验原则分为试验组和对照组,每组各35例,对照组患者采用甲硝唑联合左氧氟沙星治疗,在对照组治疗基础上,试验组患者联合切开挂线治疗,观察分析病原菌、血浆内毒素、治疗有效率、复发率等指标评估临床疗效。结果治疗后,试验组患者真菌、金黄色葡萄球菌、大肠埃希菌病原菌菌落数均低于对照组(P0.05);试验组患者血浆内毒素水平低于对照组(P0.05);试验组患者治疗总有效率91.43%,高于对照组68.57%(P0.05);试验组复发率为2.86%,低于对照组11.43%(P0.05)。结论对肛周脓肿感染患者,切开挂线联合甲硝唑、左氧氟沙星治疗,有利于改善肛周病原菌数量,防止血浆内毒素水平升高,提高临床治疗效果,降低复发率,值得临床积极推广和应用。
[Abstract]:Objective to analyze the effect of incision and thread combined with metronidazole and levofloxacin on plasma endotoxin level and pathogenic bacteria in patients with perianal abscess infection. Methods from September 2015 to September 2016, 70 patients with perianal abscess infection were selected. According to the principles of randomized, controlled and double-blind trials, they were divided into two groups, 35 cases in each group. The patients in the control group were treated with metronidazole combined with levofloxacin. On the basis of the treatment in the control group, the patients in the experimental group were treated with incision and thread, and the pathogenic bacteria, plasma endotoxin, effective rate and recurrence rate were observed and analyzed. Results after treatment, the number of fungi, Staphylococcus aureus and Escherichia coli in the experimental group was lower than that in the control group (P0.05), and the plasma endotoxin level in the experimental group was lower than that in the control group (P0.05). The total effective rate of treatment in the trial group was 91.43, which was higher than that in the control group (68.57%) (P0.05), and the recurrence rate in the trial group was 2.86%, lower than that in the control group (11.43%) (P0.05). Conclusion for the patients with perianal abscess infection, the treatment of incision combined with metronidazole and levofloxacin is beneficial to improve the number of pathogenic bacteria around the anus, prevent the increase of plasma endotoxin level, improve the clinical treatment effect and reduce the recurrence rate. It is worth popularizing and applying in clinic.
【作者单位】：齐河县人民医院普外科;
【基金】：山东省自然科学基金资助项目(ZR2009CL018)
【分类号】：R446.5;R657.15

【相似文献】