侵袭性血管黏液瘤临床病理分析

发布时间：2018-11-06 21:25

【摘要】：目的探讨侵袭性血管黏液瘤(aggressive angiomyxoma,AAM)的临床病理学特征、鉴别诊断及治疗方法。方法对3例AAM的临床病理特点进行回顾性研究,采用免疫组织化学染色,检测AAM组织中雌激素受体(ER)、孕激素受体(PR)、结蛋白(desmin)、平滑肌肌动蛋白(SMA)、波形蛋白(VIM)、S-100、CD34和CD117的表达水平,并对其治疗及预后进行随访。结果 3例AAM患者均为女性,年龄27~44岁,肿瘤发生于外阴或盆腔,3例均表达desmin、VIM、ER、PR,SMA在2例呈阳性表达,1例为阴性表达。所有病例均不表达S-100、CD34及CD117。3例患者均行肿瘤局部切除术,随访43~70月,其中1例患者于随访30月时复发一次,所有患者随访至今均无瘤存活。结论 AAM是一种少见肿瘤,容易局部复发,但不发生转移,组织学表现及免疫组织化学染色对其病理诊断具有重要作用,手术切除是目前主要的治疗方式,患者应长期随访。
[Abstract]:Objective to investigate the clinicopathological features, differential diagnosis and treatment of invasive hemangiomyxoma (aggressive angiomyxoma,AAM). Methods the clinicopathological features of 3 cases of AAM were retrospectively studied. The estrogen receptor (ER), progesterone receptor (PR), desmin (desmin), smooth muscle actin (SMA), in AAM tissues was detected by immunohistochemical staining. The expression of vimentin S-100 and CD-34 and CD117 were followed up for treatment and prognosis. Results all the 3 cases of AAM were female, aged 2744 years. The tumor occurred in vulva or pelvic cavity. The positive expression of desmin,VIM,ER,PR,SMA was found in 2 cases and negative in 1 case. All the patients did not express S-100T CD34 and CD117.3 patients underwent local tumor resection, followed up for 43 ~ 70 months. One patient recurred at 30 months, and all the patients survived without tumor. Conclusion AAM is a rare tumor with local recurrence, but no metastasis. Histological findings and immunohistochemical staining play an important role in the pathological diagnosis of AAM. Surgical resection is the main treatment at present, and patients should be followed up for a long time.
【作者单位】：四川大学华西第二医院病理科出生缺陷与相关妇儿疾病教育部重点实验室;
【分类号】：R738.6

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