老年下肢骨科手术患者认知功能及炎症因子水平的变化

发布时间：2018-11-11 10:23

【摘要】：目的探讨老年下肢骨科手术患者认知功能及炎症因子水平的变化。方法选取老年骨科手术患者89例,术前1 d、术后3 d和5 d采用简易智能状态量表(MMSE)评价,且同时检测肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-6的含量。结果术后2 d共诊断出术后认知功能障碍(POCD)患者19例(21.3%)。POCD组患者MMSE各项指标评分结果显示,与术前1 d比较,术后2 d除时间定向外,其他指标均有下降(P0.05);POCD患者TNF-α、IL-1β在术后均有下降,IL-6在术后先升后降。术前POCD组患者TNF-α、IL-1β显著高于对照组(P0.05),但术后5 d差异不显著。POCD患者术后2 d IL-6显著高于对照组(P0.05),而对照组各因子的变化相对平稳。结论 TNF-α、IL-1β、IL-6与老年下肢骨科手术后POCD的发生密切相关。
[Abstract]:Objective to investigate the changes of cognitive function and inflammatory factors in elderly patients undergoing orthopaedic surgery of lower extremities. Methods Eighty-nine patients undergoing orthopedic surgery in the elderly were evaluated by (MMSE) on day 1, day 3 and day 5 after operation. Tumor necrosis factor (TNF)-伪 and interleukin (IL)-1 尾 were detected at the same time. The content of IL-6. Results A total of 19 patients with postoperative cognitive dysfunction (POCD) were diagnosed 2 days after operation (21.3% of). POCD patients). The results of MMSE scores showed that, compared with preoperative day 1, the postoperative time orientation was 2 days after operation. Other indexes were decreased (P0.05); The levels of TNF- 伪 and IL-1 尾 in POCD patients decreased after operation, and IL-6 increased first and then decreased. TNF- 伪 and IL-1 尾 in POCD group were significantly higher than those in control group (P0.05), but there was no significant difference at 5 days after operation. IL-6 in POCD group was significantly higher than that in control group 2 days after operation (P0.05), but the change of factors in control group was relatively stable. Conclusion TNF- 伪, IL-1 尾, IL-6 are closely related to the occurrence of POCD after orthopedic surgery in the elderly lower extremities.
【作者单位】：济南市第三人民医院手外烧伤科;济南市第三人民医院门诊部;济南市第三人民医院皮肤科门诊;
【分类号】：R614.2

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