普瑞巴林联合神经妥乐平治疗脊髓损伤患者神经病理性疼痛的疗效观察

发布时间：2018-11-22 18:32

【摘要】：目的:探讨神经妥乐平对于脊髓损伤后神经病理性疼痛的临床疗效,同时比较单独使用神经妥乐平与联合使用普瑞巴林和神经妥乐平对神经病理性疼痛的缓解程度、对患者情绪以及睡眠状况的改善情况。方法:选取符合入组标准的脊髓损伤伴神经病理性疼痛患者62例,电脑随机分2组,分别为神经妥乐平组、普瑞巴林联合神经妥乐平组,神经妥乐平组起始剂量为4U bid,普瑞巴林联合神经妥乐平组起始剂量为普瑞巴林75mg bid+神经妥乐平4U bid,间隔3d调整药物剂量,疗程为4周。采用视觉模拟评分量表(visual analogue scale,VAS)、医院焦虑抑郁量表(hospital anxiety and depression scale,HAD)、匹茨堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)对患者进行疼痛、情绪和睡眠质量的评估。由专业的康复治疗师对患者服药前和疗程结束后的疗效分别进行评估。结果:单独使用神经妥乐平可以缓解脊髓损伤患者神经病理性疼痛,同时改善患者睡眠质量,治疗前后比较差异有显著性意义(P0.05);而联合使用普瑞巴林和神经妥乐平治疗后,患者的VAS和HAD评分均较神经妥乐平组明显降低,差异有显著性意义(P0.05)。结论:神经妥乐平可以缓解脊髓损伤患者的疼痛症状,联合使用普瑞巴林和神经妥乐平不仅明显缓解脊髓损伤神经病理性疼痛患者的疼痛症状,同时显著改善了患者的焦虑抑郁情绪,提高患者睡眠质量,进而提升患者生存质量,是一种有效的临床治疗方法。
[Abstract]:Objective: to investigate the clinical effect of neuropathic pain after spinal cord injury (sci), and to compare the effect of neuropathic pain treated with neuropathic pain treated by neurotropin alone and combined with prazin and neurotropin. Improved mood and sleep status of patients. Methods: Sixty-two patients with spinal cord injury and neuropathic pain were randomly divided into two groups: neurotropin group, pragabine combined with neurotropin group, and neurotropin group with initial dose of 4 U bid,. The initial dose of preabine combined with neurotropin was adjusted 3 days after injection of 75mg bid neurotropin 4U bid,. The course of treatment was 4 weeks. Visual analogue scale (visual analogue scale,VAS), Hospital anxiety and Depression scale (hospital anxiety and depression scale,HAD) and Pittsburgh Sleep quality Index (Pittsburgh sleep quality index,PSQI) were used to evaluate pain, mood and sleep quality. Patients were evaluated before and after treatment by a professional rehabilitation therapist. Results: neuropathic pain was alleviated in patients with spinal cord injury and sleep quality was improved. There was significant difference before and after treatment (P0.05). However, the VAS and HAD scores of patients treated with prednisoline and neurotropin were significantly lower than those of neurotropin group (P0.05). Conclusion: neurotropin can relieve the pain symptoms of patients with spinal cord injury, and the combination of prazin and neurotropin can not only relieve the pain symptoms of patients with spinal cord injury neuropathic pain, but also can relieve the pain symptoms of patients with spinal cord injury neuropathic pain. At the same time, it can significantly improve the anxiety and depression of the patients, improve the sleep quality of the patients, and then improve the quality of life of the patients. It is an effective clinical treatment.
【作者单位】：中山大学孙逸仙纪念医院康复科;
【基金】：广东省医学科研基金项目(A2015308) 广东省自然科学基金-重点项目(2016A030311045) 广州市科学技术研究专项基金项目(201607010254)
【分类号】：R651.2

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