Hedgehog信号通路调节成骨细胞RANKL表达的研究进展

发布时间：2018-11-29 14:06

【摘要】：背景:Hedgehog信号通路不仅参与骨髓间充质干细胞的成骨向分化,而且是位于RANKL-RANK-OPG系统调节轴上游的重要通路之一,对成骨细胞RANKL的分泌表达具有重要的调控作用,其调控机制已逐步被揭示。目的:对Hedgehog信号通路调控成骨细胞RANKL表达的研究现状进行综述。方法:通过检索CNKI,Google Scholar,PubM ed等数据库,分别以"Hedgehog,成骨细胞,骨髓间充质干细胞,甲状旁腺激素相关蛋白,环磷酸腺苷应答元件结合蛋白,活化T细胞核因子,核因子κB受体活化因子配体"和"Hedgehog,Osteoblast,BMSCs,PTHrP,CREB,NFAT,RANKL"为检索词进行检索,审阅有关Hedgehog信号通路与成骨细胞RANKL表达相关的文献,根据纳入标准最终选取37篇文献进行综述。结果与结论:Hedgehog信号蛋白可促使骨髓间充质干细胞向成骨细胞分化,同时又可以通过上调细胞内甲状旁腺激素相关蛋白的表达,进一步激活下游细胞因子环磷酸腺苷应答元件结合蛋白和活化T细胞核因子,两者协同促使成骨细胞RANKL基因表达,进而增加破骨前体细胞向破骨细胞分化、成熟。
[Abstract]:Background: Hedgehog signaling pathway not only participates in the osteogenic differentiation of bone marrow mesenchymal stem cells, but also is one of the important pathways upstream of the regulatory axis of the RANKL-RANK-OPG system. It plays an important role in regulating the secretion and expression of RANKL in osteoblasts. Its regulatory mechanism has been gradually revealed. Objective: to review the current status of Hedgehog signaling pathway regulating RANKL expression in osteoblasts. Methods: Hedgehog, osteoblasts, bone marrow mesenchymal stem cells, parathyroid hormone related protein, cyclic adenosine monophosphate responsive element binding protein, T nuclear factor were activated by searching CNKI,Google Scholar,PubM ed and other databases. Nuclear factor- 魏 B receptor activator ligands "and" Hedgehog,Osteoblast,BMSCs,PTHrP,CREB,NFAT,RANKL "were searched for information on the relationship between Hedgehog signaling pathway and RANKL expression in osteoblasts. According to the inclusion criteria, 37 articles were selected for review. Results & conclusion: Hedgehog signaling protein can induce the differentiation of bone marrow mesenchymal stem cells into osteoblasts and up-regulate the expression of parathyroid hormone related proteins in the cells. Further activation of downstream cytokine adenosine monophosphate responsive element binding protein and activation of T cell nuclear factor, both of which synergistically promote osteoblast RANKL gene expression, and then increase osteoclast differentiation to osteoclast differentiation and maturation.
【作者单位】：广西医科大学附属口腔医院修复科;
【基金】：国家自然科学基金资助项目(81260170)~~
【分类号】：R68

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