微创手术治疗老年胆总管结石的疗效及对CA19-9水平的影响

发布时间：2018-12-09 12:34

【摘要】：目的观察微创手术治疗胆总管结石的效果及对血清糖类抗原(CA)19-9水平的影响。方法选取胆总管结石患者90例,随机分为对照组(n=45)和观察组(n=45)。对照组采用开腹手术治疗,观察组采用微创手术治疗。采用放射免疫法测定CA19-9和癌胚抗原(CEA)水平,采用免疫比浊法测定C反应蛋白(CRP)水平,比较两组治疗效果及对血清CA19-9水平的影响。结果观察组手术时间、术中出血量、肛门排气时间及住院时间显著少于对照组(P0.05);两组术前CA19-9、CEA及CRP水平差异无统计学意义(P0.05);观察组术后CA19-9、CEA及CRP水平显著低于对照组(P0.05);观察组术后并发症发生率为4.44%,显著低于对照组的17.78%(P0.05)。结论胆总管结石患者采用微创手术治疗效果理想,能降低机体血清CA19-9水平。
[Abstract]:Objective to observe the effect of minimally invasive surgery on choledocholithiasis and the level of serum carbohydrate antigen (CA) 19 9. Methods 90 patients with choledocholithiasis were randomly divided into control group (n = 45) and observation group (n = 45). The control group was treated by open surgery, and the observation group by minimally invasive surgery. The levels of CA19-9 and carcinoembryonic antigen (CEA) were measured by radioimmunoassay, and C-reactive protein (CRP) (CRP) were measured by immunoturbidimetry. The therapeutic effect and the effect on serum CA19-9 level were compared between the two groups. Results the operative time, intraoperative bleeding volume, anal exhaust time and hospitalization time in the observation group were significantly less than those in the control group (P0.05), and there was no significant difference between the two groups in preoperative CA19-9,CEA and CRP levels (P0.05). The levels of CA19-9,CEA and CRP in the observation group were significantly lower than those in the control group (P0.05), and the incidence of postoperative complications in the observation group was 4.44, which was significantly lower than that in the control group (17.78%) (P0.05). Conclusion minimally invasive surgery is effective in the treatment of choledocholithiasis and can reduce the level of serum CA19-9 in patients with choledocholithiasis.
【作者单位】：济源市人民医院肝胆外科;济源市妇幼保健院(中西医结合)外科;宁夏医科大学;
【基金】：国家自然科学基金项目(No.81560769)
【分类号】：R657.42

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