接骨药丸预防人工全膝关节假体无菌性松动的临床观察

发布时间：2018-12-11 13:41

【摘要】：目的：观察接骨药丸对人工全膝关节置换术后假体周围骨密度值的影响,探讨整骨接骨药丸治疗假体无菌性松动的作用,为接骨药丸在预防和治疗人工全膝关节置换术后假体无菌性松动提供临床依据。方法：本研究纳入80例需行初次人工全膝关节置换患者,予以随机分为接骨药丸组和对照组；术后第2周接骨药丸组予以接骨药丸6g+钙尔奇D 0.6g,对照组予以钙尔奇D 0.6g,每天一次,3个月为一个疗程,两疗程间间隔2周,共治疗3个疗程。3个疗程结束后,使用XR-800全身骨密度测量仪检测膝关节假体周围各区的骨密度值(BMD),采用酶联免疫吸附法(ELISA)分别检测ALP和TRAP含量。结果：1.接骨药丸组与对照组在治疗前BMD值均无显著性差异(P0.05)；在接骨药丸组与对照组比较,接骨药丸组经治疗后假体周围BMD值明显高于对照组(P0.05).2.A LP含量接骨药丸组与对照组在治疗后均有明显增加；但接骨药丸组在治疗后ALP含量高于对照组(P0.05)。3.TRAP含量接骨药丸组与对照组在治疗后均有降低；但接骨药丸组在治疗后TRAP含量显著低于对照组(P0.05)。结论：1.接骨药丸较对照组可明显改善人工全膝关节假体周围骨质,提高骨密度,促进骨生成,抑制骨破坏,增强对假体的支撑作用。2.接骨药丸具有服用方便、副作用少优点。可作为人工全膝关节置换术后假体无菌性松动预防用药。
[Abstract]:Objective: to observe the effect of Jiegu pills on bone mineral density (BMD) of prosthesis after total knee arthroplasty, and to explore the effect of Jiegu pills on aseptic loosening of prosthesis. To provide clinical basis for the prevention and treatment of prosthetic aseptic loosening after total knee arthroplasty. Methods: 80 patients with primary total knee arthroplasty were randomly divided into two groups: group B and control group. At the second week after operation, the group of Jiegu pills was given 6g of calachylic D 0.6 g, and the control group was given 0.6 g of calcareous D, once a day, 3 months as a course of treatment, the interval between two courses of treatment was 2 weeks, a total of 3 courses of treatment were treated after the end of 3 courses of treatment. Bone mineral density (BMD) around the prosthesis of knee joint was measured by XR-800 whole body bone mineral density (BMD). The contents of ALP and TRAP were detected by enzyme-linked immunosorbent assay (ELISA). Results: 1. There was no significant difference in BMD between the two groups before treatment (P0.05). Compared with the control group, the BMD value around the prosthesis in the Jiegu pill group was significantly higher than that in the control group (P0.05). 2. The content of LP in the Jiegu pill group and the control group were significantly increased after treatment. However, the content of ALP in Jiegu pill group was higher than that in control group after treatment (P0.05). The 3.TRAP content in Jiegu pill group and control group were decreased after treatment, but the TRAP content in Jiegu pill group was significantly lower than that in control group after treatment (P0.05). Conclusion: 1. Compared with the control group, Jiegu pill can obviously improve the bone around artificial total knee prosthesis, increase bone density, promote bone formation, inhibit bone destruction, and enhance the supporting effect on prosthesis. 2. Jiegu pills have the advantages of convenient taking and less side effects. It can be used as prophylaxis of aseptic loosening of prosthesis after total knee arthroplasty.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R687.4

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