磁场对兔子骨骼力学性能的影响

发布时间：2018-12-12 07:42

【摘要】：现阶段骨性关节炎(Osteoarthritis,OA)在人类中老年阶段发病率较高,现代医学实验已经证明,患有前中期的骨性关节炎患者,用物理学的方法进行干预是一种可行性方法。其中,用电磁场对骨性关节炎进行干预就是众多物理学方法的一种。随着当代磁场生物学研究的理论基础不断深入,其研究成果将不断的应用到实践当中。在生物力学中的一个重要分支就是骨生物力学,它是研究骨骼遭受外力后的生物效应和骨组织在外力作用下的力学特性,是判断一个骨骼优劣的基础参考依据。所以本文通过研究兔子股骨各骨质层体积的变化以及对股骨力学性能的评估,并运用COMSOL软件进行仿真模拟兔子股骨周围磁场分布。结合实验数据与仿真结果分析磁场的作用对患骨性关节炎兔子股骨的影响。本次实验将3只新西兰大白兔随机的分为两组:实验组(2只)与对照组(1只)。实验组对成年新西兰大白兔的右后腿股骨关节腔注射浓度为3%的木瓜蛋白酶使其破坏关节软骨,建立典型的OA模型,然后将实验组的兔子放入磁疗箱进行物理干预,对照组正常饲养不参与实验。接着通过医学影像CT扫描获取兔子股骨各骨质层的体积,常规股骨生物力学实验获取有相关力学性能参数,之后对股骨骨质层体积与力学实验数据进行整合与分析。最后利用有限元的方法对实验结果进行仿真,得出兔子股骨处磁感应强度大小与磁场分布。与实验测的数据进行比较,仿真结果与实验数据基本吻合。通过CT扫描结果可以看出在打药后用75Hz磁场物理干预的兔子的右后腿股骨的各骨质层的变化趋势曲线相比用25Hz的曲线趋势更趋于对照组;通过三点弯曲实验的结果可以看出用75Hz磁场物理干预的兔子右后腿股骨的最大承载载荷、断裂强度以及最大弯曲正应力均高于25Hz磁场干预的兔子。结论:75Hz的磁场在修复OA兔子的效果上更优于25Hz的磁场。
[Abstract]:At present, the incidence of osteoarthritis (Osteoarthritis,OA) is relatively high in the middle and old age. Modern medical experiments have proved that physical intervention is a feasible method for patients with osteoarthritis. Intervention in osteoarthritis with electromagnetic fields is one of many physical methods. With the deepening of the theoretical foundation of contemporary magnetic field biology, its research results will be applied to practice. Bone biomechanics is an important branch of biomechanics. It is a basic reference for studying the biomechanical effect of bone under external force and the mechanical properties of bone tissue under external force. Therefore, this paper studies the changes of femoral bone layer volume and the evaluation of femoral mechanical properties, and simulates the distribution of magnetic field around the femur by using COMSOL software. The effect of magnetic field on femur of rabbits with osteoarthritis was analyzed with experimental data and simulation results. Three New Zealand rabbits were randomly divided into two groups: experimental group (n = 2) and control group (n = 1). The experimental group injected 3% papain into the femur of the right hind leg of adult New Zealand white rabbits to destroy the articular cartilage and set up a typical OA model. Then the rabbits of the experimental group were put into the magnetic therapy box for physical intervention. The control group did not participate in the experiment. Then the volume of bone layers of femur was obtained by CT scanning of medical image, and the parameters of mechanical properties were obtained by routine femoral biomechanical experiment, and then the volume of femoral bone layer and the data of mechanical experiment were integrated and analyzed. Finally, the finite element method is used to simulate the experimental results, and the magnitude of magnetic induction and magnetic field distribution in rabbit femur are obtained. Compared with the experimental data, the simulation results are in good agreement with the experimental data. The results of CT scan showed that the trend curve of femur of right hind leg of rabbits treated with 75Hz magnetic field physical intervention was more similar to that of control group compared with that of 25Hz. The results of three-point bending experiment show that the maximum load, fracture strength and maximum bending normal stress of femur of right hind leg of rabbits treated with 75Hz magnetic field are higher than those of rabbits treated with 25Hz magnetic field. Conclusion: the magnetic field of 75Hz is better than that of 25Hz in repairing OA rabbits.
【学位授予单位】：新疆大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684.3

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