可吸收形状记忆聚氨酯腰椎间融合器的生物力学评价

发布时间：2018-12-12 15:46

【摘要】：目的:评价自主研制的可吸收形状记忆聚氨酯(shape memory polyurethane,SMPU)腰椎间融合器(cage)在尸体腰椎单节段的生物力学特性。方法:将15具腰骶椎(L1?S1)标本随机分为3组:自体髂骨组(n=5),SMPU cage组(n=5),聚醚醚酮(polyetheretherketone,PEEK)cage组(n=5)。通过腰椎侧方入路,摘除L3?4椎间盘髓核后植入3种内植物,在力学试验机上测试每组标本术前与术后的运动范围(range of motion,ROM)及轴向破坏载荷。结果:ROM结果显示:术前自体髂骨组、SMPU cage组及PEEK cage组在前屈、后伸、左侧弯、右侧弯、左旋转、右旋转6个方向上的ROM相比较,差异均无统计学意义(P0.05)。自体髂骨组在6个方向上的术后ROM均较术前明显增加(P0.05);SMPU cage组在6个方向上的术后ROM均较术前明显减少(P0.05);PEEK cage组在6个方向上的术后ROM均较术前明显减少(P0.05)。SMPU cage组与PEEK cage组术后在6个方向上的ROM均显著低于自体髂骨组(P0.05);SMPU cage组与PEEK cage组术后在6个方向上的ROM相比较,差异无统计学意义(P0.05)。轴向压缩测试结果显示:PEEK cage组的破坏载荷较SMPU cage组和自体髂骨组明显增加(P=0.000),SMPU cage组的破坏载荷较自体髂骨组明显增加(P=0.000)。结论:形状记忆聚氨酯椎间融合器能满足腰椎椎间融合的初始稳定性,并能够承载腰椎的生理负荷。
[Abstract]:Aim: to evaluate the biomechanical characteristics of an absorbable shape memory polyurethane (shape memory polyurethane,SMPU) lumbar interbody fusion cage (cage) in single segment of cadaveric lumbar spine. Methods: fifteen lumbosacral vertebrae (L1?S1) specimens were randomly divided into 3 groups: autogenous iliac bone group (n = 5) (n = 5), polyether ether ketone (polyetheretherketone,PEEK) group (n = 5) cage group (n = 5). Three kinds of implants were implanted into the lumbar disc nucleus pulposus by lateral approach of lumbar vertebrae. The range of motion (range of motion,ROM) and the axial damage load of each group were measured by mechanical testing machine before and after operation. Results: the results of ROM showed that there was no significant difference in ROM between, SMPU cage group and PEEK cage group in 6 directions: anterior flexion, extension, left bend, right bend, left rotation and right rotation (P0.05). The postoperative ROM in the autogenous iliac bone group was significantly higher than that in the preoperative group (P0.05). The postoperative ROM in the); SMPU cage group was significantly lower than that in the pre-operation group (P0.05). The postoperative ROM of PEEK cage group in 6 directions was significantly lower than that of preoperative group (P0.05). The ROM of). SMPU cage group and PEEK cage group were significantly lower than that of autogenous iliac bone group (P0.05). There was no significant difference in ROM in 6 directions between SMPU cage group and PEEK cage group (P0.05). The results of axial compression test showed that the damage load of: PEEK cage group was significantly higher than that of SMPU cage group and autogenous iliac bone group (P0. 000), SMPU cage group was significantly higher than that of autologous iliac bone group (P0. 000). Conclusion: shape memory polyurethane interbody fusion cage can satisfy the initial stability of lumbar interbody fusion and can bear the physiological load of lumbar vertebrae.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R687

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