导管溶栓术治疗下肢深静脉血栓形成的疗效及对患者生活质量的影响

发布时间：2018-12-14 05:11

【摘要】：目的探讨导管溶栓术(catheter-directed thrombolysis,CDT)和系统溶栓治疗下肢深静脉血栓形成(lower extremity deep vein thrombosis,LEDVT)的临床疗效,以及对患者生活质量的影响。方法选择宁夏医科大学第二附属医院血管外科2010年10月-2014年10月收治符合标准的LEDVT患者60例,随机分为观察组和对照组各30例。观察组采用CDT,对照组采用系统溶栓法治疗,比较两组患者患肢治疗情况。结果观察组患者患肢大腿中段消肿率、患肢小腿中段消肿率、患肢溶栓率均高于对照组(P均0.05);两组患者均获得1年随访,结果显示观察组在患肢深静脉通畅率、再发LEDVT率、髂静脉闭塞率及CEAP分级方面均优于对照组(P0.05);治疗1年后,两组患者SF-36各维度得分较治疗前均提高(P均0.05);但观察组SF-36各维度得分提高幅度大于对照组(P0.05)。结论 CDT治疗LEDVT近期及远期疗效均优于系统溶栓,改善患者生活质量,值得临床推广应用。
[Abstract]:Objective to investigate the clinical effect of catheter thrombolysis (catheter-directed thrombolysis,CDT) and systemic thrombolysis on deep venous thrombosis (lower extremity deep vein thrombosis,LEDVT) of lower extremity and its effect on quality of life. Methods from October 2010 to October 2014, 60 patients with LEDVT were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30). The patients in the observation group were treated with systemic thrombolytic therapy in CDT, control group. Results the detumescence rate of middle thigh, middle leg and thrombolytic rate of the patients in the observation group were higher than those in the control group (P 0.05). The results showed that the patency rate of deep vein, recurrent LEDVT rate, iliac vein occlusion rate and CEAP grading in the observation group were better than those in the control group (P0.05). After one year of treatment, the scores of each dimension of SF-36 in the two groups were higher than those before treatment (P 0.05), but the scores of each dimension of SF-36 in the observation group were higher than those in the control group (P0.05). Conclusion CDT is better than systemic thrombolytic therapy in the short and long term in treating LEDVT, and it is worth popularizing in clinic.
【作者单位】：宁夏医科大学第二附属医院血管外科;
【分类号】：R654.4

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