甲状旁腺激素联合葛根素对老年骨质疏松性股骨粗隆骨折术后影响的临床观察
发布时间：2018-12-15 21:20
【摘要】：目的研究甲状旁腺激素联合葛根素对老年骨质疏松性股骨粗隆骨折术后的影响,为老年骨质疏松性粗隆骨折寻找安全可靠、疗效良好的治疗方案。方法 2013年1月至2015年1月间收治的老年性骨质疏松性股骨粗隆骨折88例,采用随机数字表法将其分为治疗组和对照组,每组44例,两组患者均接受PFNA治疗。对照组予以葛根素治疗,治疗组术后加用甲状旁腺激素治疗,比较两组患者治疗后患者视觉模拟痛疼评分(VAS)、髋关节Harris功能评分、骨折愈合时间及股骨颈及腰椎的骨密度改变。结果术后1周、3个月、6个月两组患者VAS评分均明显降低,且治疗组患者评分明显低于对照组(P0.05);术后3个月、6个月两组患者的Harris评分均明显上升,且治疗组患者评分明显高于对照组(P0.05);治疗组骨折愈合的时间明显少于对照组(P0.05);术后3个月、6个月两组患者股骨颈及腰椎的骨密度,治疗组患者骨密度较术前显著改善(P0.05),而对照组治疗前后上述指标无明显变化(P0.05)。结论甲状旁腺激素联合葛根素可以明显加速老年骨质疏松性粗隆骨折愈合、改善预后。
[Abstract]:Objective to study the effect of parathyroid hormone (PTH) combined with puerarin on senile osteoporotic femoral trochanteric fracture and to find a safe and effective treatment for senile osteoporotic trochanteric fracture. Methods 88 cases of senile osteoporotic femoral trochanteric fractures were treated from January 2013 to January 2015. They were randomly divided into treatment group (n = 44) and control group (n = 44). The patients in both groups were treated with PFNA. The patients in the control group were treated with puerarin and the patients in the treatment group were treated with parathyroid hormone after operation. The visual analogue pain score (VAS),) and Harris score of hip joint were compared between the two groups after treatment. Fracture healing time and bone mineral density of femoral neck and lumbar vertebrae. Results at 1 week, 3 months and 6 months after operation, the VAS scores of the two groups were significantly lower than those of the control group (P0.05), and the scores of the patients in the treatment group were significantly lower than those in the control group (P0.05). After 3 months, 6 months after operation, the Harris scores of the two groups were significantly increased, and the scores of the patients in the treatment group were significantly higher than those in the control group (P0.05), the time of fracture healing in the treatment group was significantly less than that in the control group (P0.05). The bone mineral density of femoral neck and lumbar vertebrae was significantly improved in the treatment group 3 months and 6 months after operation (P0.05), but there was no significant change in the control group before and after treatment (P0.05). Conclusion parathyroid hormone combined with puerarin can accelerate the healing of osteoporosis fracture and improve the prognosis.
【作者单位】： 佛山市中医院;
【分类号】：R580;R687.3
，
本文编号：2381309
[Abstract]:Objective to study the effect of parathyroid hormone (PTH) combined with puerarin on senile osteoporotic femoral trochanteric fracture and to find a safe and effective treatment for senile osteoporotic trochanteric fracture. Methods 88 cases of senile osteoporotic femoral trochanteric fractures were treated from January 2013 to January 2015. They were randomly divided into treatment group (n = 44) and control group (n = 44). The patients in both groups were treated with PFNA. The patients in the control group were treated with puerarin and the patients in the treatment group were treated with parathyroid hormone after operation. The visual analogue pain score (VAS),) and Harris score of hip joint were compared between the two groups after treatment. Fracture healing time and bone mineral density of femoral neck and lumbar vertebrae. Results at 1 week, 3 months and 6 months after operation, the VAS scores of the two groups were significantly lower than those of the control group (P0.05), and the scores of the patients in the treatment group were significantly lower than those in the control group (P0.05). After 3 months, 6 months after operation, the Harris scores of the two groups were significantly increased, and the scores of the patients in the treatment group were significantly higher than those in the control group (P0.05), the time of fracture healing in the treatment group was significantly less than that in the control group (P0.05). The bone mineral density of femoral neck and lumbar vertebrae was significantly improved in the treatment group 3 months and 6 months after operation (P0.05), but there was no significant change in the control group before and after treatment (P0.05). Conclusion parathyroid hormone combined with puerarin can accelerate the healing of osteoporosis fracture and improve the prognosis.
【作者单位】： 佛山市中医院;
【分类号】：R580;R687.3
，
本文编号：2381309
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