钽棒置入联合外周血干细胞介入治疗早期股骨头坏死

发布时间：2018-12-28 17:34

【摘要】：目的评估钽棒置入联合外周血干细胞介入治疗早期股骨头坏死(ON)的临床疗效。方法笔者自2009-01—2011-08采用钽棒置入治疗28例(43髋)ON,并于钽棒置入1~2周后进行了外周血干细胞介入,部分患者4~6周后接受第2次细胞疗法。结果 27例(42髋)获得平均48(36~60)个月随访,1例(1髋)失访,无一例死亡。术后36个月时股骨头的生存率为91.7%,HHS评分从术前的(56.3±12.8)分改善为术后的(90.5±19.3)分,差异有统计学意义(t=9.224,P0.001)。39髋HHS评分优26髋,良10髋,可3髋,优良率92.3%。第2次介入发现股骨头内血管数目增多,血管变粗。术后1例发生大粗隆部位的滑囊炎,未发生其他术后并发症。结论钽棒置入联合外周血干细胞介入治疗早期股骨头坏死可以有效缓解疼痛,改善髋关节功能、避免或者延迟关节置换手术,应用前景广阔。
[Abstract]:Objective to evaluate the clinical effect of tantalum rod implantation combined with peripheral blood stem cell intervention in the treatment of early avascular necrosis of femoral head (ON). Methods 28 patients (43 hips) with ON, were treated with tantalum rod implantation from 2009-01-2011-08. Peripheral blood stem cells (PBSC) intervention was performed 2 weeks after tantalum rod implantation. Results 27 cases (42 hips) were followed up for an average of 48 months, 1 case (1 hip) lost a visit, none died. At 36 months after operation, the survival rate of femoral head improved from (56.3 卤12.8) to (90.5 卤19.3), and the HHS score of 39 hips was excellent in 26 hips. Good 10 hips, fair 3 hips, excellent and good rate 92.3%. In the second intervention, the number of vessels in the femoral head increased and the blood vessels became thicker. One case developed bursitis at the large trochanter site, and no other postoperative complications occurred. Conclusion Tantalum rod implantation combined with peripheral blood stem cell intervention for early femoral head necrosis can effectively relieve pain, improve hip function, and avoid or delay joint replacement surgery.
【作者单位】：浙江中医药大学第一临床医学院骨伤科;浙江中医药大学骨伤研究所;
【基金】：中国博士后科学基金面上项目(2014M561793);中国博士后科学基金特别资助(2015T80637) 浙江省重点科技创新团队自主项目(2011R50022-02) 浙江省中医药科技计划项目(2013ZQ007) 2013国家自然科学基金青年项目(81302989)
【分类号】：R687.3

【相似文献】