注射透明质酸与自体脂肪颗粒移植治疗鼻唇沟皱褶疗效的对比分析
发布时间：2019-01-01 15:09
【摘要】：目的：对比注射透明质酸与自体脂肪颗粒移植治疗鼻唇沟皱褶的有效性和安全性。方法：60例鼻唇沟部皱纹严重程度分级在中度以上的患者随机分为A、B两组,每组各30人,A组接受透明质酸注射治疗,B组接受自体脂肪颗粒移植治疗,随访12个月,分别由研究者和受试者根据皱纹严重程度评分表和面部整体美容效果改善分级进行评分,研究者记录不良事件的发生情况。结果：两组受试者使用填充物注射总剂量(注射剂量+补充剂量)B组大于A组(P0.05)；研究者和受试者分别在治疗前后各个时间点评价鼻唇沟皱纹严重程度,治疗后3个月,鼻唇沟皱纹严重程度的评分先是明显下降,随后治疗后6、12个月的随访中评分略增高,但均未超过治疗前评分；治疗后12个月,研究者与受试者分别评价鼻唇沟皱纹严重程度(WSRS),B组评分低于A组(P0.05),即B组治疗效果优于A组；治疗后12个月,研究者与受试者分别评价面部整体美容效果改善分级(GAIS),B组满意率高于A组(P0.05)；治疗后12个月内发红、瘙痒的发生率A组高于B组(P0.05),肿胀、疼痛和硬结的发生率两组之间无差别(P0.05)。结论：在治疗鼻唇沟皱褶方面,自体脂肪颗粒移植比注射透明质酸的维持时间长、外形自然、并发症少,值得推广应用。
[Abstract]:Objective: to compare the efficacy and safety of injecting hyaluronic acid and autologous fat granules in the treatment of nasolabial crease. Methods: sixty patients with severe degree of wrinkle in nasolabial sulcus were randomly divided into two groups: group A received hyaluronic acid injection, group B received autogenous fat granule transplantation, and the patients were followed up for 12 months. According to the score of wrinkle severity scale and the overall facial beauty improvement grade, the researchers recorded the occurrence of adverse events. Results: the total dose of filling was higher in group B than in group A (P0.05). The researchers and subjects evaluated the severity of nasolabial furrow at different time points before and after treatment. After 3 months of treatment, the score of the severity of nasolabial furrow decreased significantly, then increased slightly during the follow-up of 6 months and 12 months after treatment. But none of them exceeded the score before treatment. At 12 months after treatment, the score of nasolabial furrow severity in (WSRS), B group was lower than that in A group (P0.05), that is, the therapeutic effect of group B was better than that of group A; 12 months after treatment, the satisfaction rate of (GAIS), B group was higher than that of A group (P0.05). Within 12 months after treatment, the incidence of pruritus in group A was higher than that in group B (P0.05). There was no difference in the incidence of swelling, pain and induration between the two groups (P0.05). Conclusion: in the treatment of nasolabial crease, autologous fat granule transplantation is worth popularizing because of its long maintenance time, natural appearance and less complications.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R622.9
本文编号：2397732
[Abstract]:Objective: to compare the efficacy and safety of injecting hyaluronic acid and autologous fat granules in the treatment of nasolabial crease. Methods: sixty patients with severe degree of wrinkle in nasolabial sulcus were randomly divided into two groups: group A received hyaluronic acid injection, group B received autogenous fat granule transplantation, and the patients were followed up for 12 months. According to the score of wrinkle severity scale and the overall facial beauty improvement grade, the researchers recorded the occurrence of adverse events. Results: the total dose of filling was higher in group B than in group A (P0.05). The researchers and subjects evaluated the severity of nasolabial furrow at different time points before and after treatment. After 3 months of treatment, the score of the severity of nasolabial furrow decreased significantly, then increased slightly during the follow-up of 6 months and 12 months after treatment. But none of them exceeded the score before treatment. At 12 months after treatment, the score of nasolabial furrow severity in (WSRS), B group was lower than that in A group (P0.05), that is, the therapeutic effect of group B was better than that of group A; 12 months after treatment, the satisfaction rate of (GAIS), B group was higher than that of A group (P0.05). Within 12 months after treatment, the incidence of pruritus in group A was higher than that in group B (P0.05). There was no difference in the incidence of swelling, pain and induration between the two groups (P0.05). Conclusion: in the treatment of nasolabial crease, autologous fat granule transplantation is worth popularizing because of its long maintenance time, natural appearance and less complications.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R622.9
【参考文献】
相关期刊论文 前1条
1 张新合,郭东来,高建华;取材方法对脂肪细胞损伤程度的人体观察[J];中华整形外科杂志;2001年05期
，本文编号：2397732
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