舒芬太尼注射液联合七氟烷吸入剂用于老年腹部手术的临床研究

发布时间：2019-01-25 08:49

【摘要】：目的观察舒芬太尼注射液联合七氟烷吸入剂用于老年腹部手术的临床疗效和安全性。方法将72例老年腹部手术患者随机分为对照组36例和试验组36例。对照组予以0.04 L·min~(-1)七氟烷混合6 L·min~(-1)纯氧,面罩吸入20~30 s;试验组在对照组治疗的基础上,予以0.4~0.5μg·kg~(-1)舒芬太尼注射液,静脉滴注,20~30 s。比较2组患者的简易智能精神状态检查量表(MMSE)评分和药物不良反应的发生情况。结果应答后1,6,12 h,试验组的MMSE分别为(23.19±2.52),(25.29±2.83)和(28.39±2.99)分,对照组的MMSE分别为(20.10±2.10),(21.39±2.39)和(24.20±2.53)分,2组比较差异均有统计学意义(均P0.05)。试验组发生的药物不良反应以高热、头痛和肌肉僵硬为主,对照组发生的药物不良反应以恶心呕吐、高热和腹泻为主。试验组和对照组的总药物不良反应发生率分别为8.33%和11.11%,差异无统计学意义(P0.05)。结论舒芬太尼注射液联合七氟烷吸入剂用于老年腹部手术的临床疗效确切,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of sufentanil injection combined with sevoflurane inhalation in elderly patients undergoing abdominal surgery. Methods 72 elderly patients undergoing abdominal surgery were randomly divided into control group (n = 36) and trial group (n = 36). In the control group, 0.04 L min~ (-1) sevoflurane was mixed with 6 L min~ (-1) pure oxygen, and the mask was inhaled for 2030 s. On the basis of treatment in control group, 0.4 渭 g kg~ (-1) sufentanil was injected intravenously for 20 ~ 30 s. The (MMSE) scores and adverse drug reactions were compared between the two groups. Results MMSE was (23.19 卤2.52), (25.29 卤2.83) and (28.39 卤2.99) in the experimental group and (20.10 卤2.10), (卤2.39) and (24.20 卤2.53) in the control group, respectively. The differences between the two groups were statistically significant (P0.05). The adverse drug reactions in the test group were high fever, headache and muscle stiffness, while in the control group, nausea and vomiting, high fever and diarrhea were the main adverse drug reactions. The incidence of total adverse drug reactions in the test group and the control group were 8.33% and 11.11%, respectively, with no significant difference (P0.05). Conclusion Sufentanil injection combined with sevoflurane inhalation is effective for abdominal surgery in the elderly and does not increase the incidence of adverse drug reactions.
【作者单位】：厦门大学附属第一医院麻醉科;
【基金】：科技惠民计划基金资助项目(3502Z20174069)
【分类号】：R614

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