定量超声测定跟骨骨密度对骨质疏松性骨折的判断价值及其与血清骨代谢、骨转化指标的相关性

发布时间：2019-01-26 07:52

【摘要】：目的分析定量超声测定跟骨骨密度(BMD)对骨质疏松性骨折的判断价值,并探讨BMD与患者血清骨代谢、骨转化指标的相关性。方法将2013年8月至2015年8月期间在北京大学深圳医院接受检查治疗的骨质疏松性骨折患者72例作为观察组,另取同期在本院接受健康体检、不伴骨质疏松的老年人群68例作为对照组,比较两组患者的定量超声下BMD值、血清骨代谢、骨转化指标值的差异,并进一步分析BMD与骨质疏松性骨折患者病情的关系。结果观察组患者的BMD为(0.23±0.04)g/cm2、25羟维生素D(25OHD)为(39.27±4.51)nmol/L、骨钙素N端中分子片段(N-MID)为(56.18±7.29)ng/m L、人降钙素(HCT)为(2.41±0.32)ng/L,均相应低于对照组的(0.35±0.05)g/cm2、(57.63±6.92)nmol/L、(82.55±9.04)ng/m L、(3.17±0.42)ng/L,而碱性磷酸酶(ALP)为(56.27±6.19)IU/L、Ⅰ型前胶原N末端前肽(PINP)为(42.18±5.29)μg/L、抗酒石酸酸性磷酸酶(TRAP)为(4.63±0.53)U/L、β-胶原降解产物(β-CTX)为(64.39±7.11)ng/m L,均高于对照组的(27.45±3.38)IU/L、(24.76±3.08)μg/L、(3.11±0.37)U/L、(45.28±5.29)ng/m L,差异均有统计学意义(P0.05)。经一元线性回归分析发现,骨质疏松性骨折患者的BMD值与血清25OHD、N-MID、HCT值呈正相关(r=0.627、0.701、0.598),与ALP、PINP、TRAP、β-CTX呈负相关(r=-0.582、-0.672、-0.693,P0.05)。结论定量超声测定跟骨骨密度可以客观判断骨质疏松性骨折的严重度,其与患者的血清学指标存在良好的相关关系,可以作为临床病情监测及预后判断的可靠手段。
[Abstract]:Objective to analyze the value of quantitative ultrasound measurement of calcaneal bone mineral density (BMD) in the diagnosis of osteoporotic fracture and to explore the correlation between BMD and serum bone metabolism and bone transformation index. Methods from August 2013 to August 2015, 72 patients with osteoporotic fracture were examined in Shenzhen Hospital of Peking University as the observation group. Sixty-eight elderly people without osteoporosis were used as control group to compare the difference of BMD value, serum bone metabolism and bone transformation index between the two groups under quantitative ultrasound, and to further analyze the relationship between BMD and the condition of patients with osteoporosis fracture. Results the BMD of the observation group was (0.23 卤0.04) g / cm ~ (2) ~ (25) hydroxyvitamin D (25OHD) = (39.27 卤4.51) nmol/L, N-MID = (56.18 卤7.29) ng/m / L, respectively. Human calcitonin (HCT) (2.41 卤0.32) ng/L, was significantly lower than that of control group (0.35 卤0. 05) g / cm ~ (2), (57.63 卤6.92) nmol/L, (82.55 卤9.04) ng/m L, (3.17 卤0.42) ng/L,. The (ALP) of alkaline phosphatase was (56.27 卤6.19) IU/L, 鈪，

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