人体颈椎黄韧带中二羟焦磷酸钙和碳羟磷灰石的矿物学成因探讨
发布时间：2019-02-12 22:47
【摘要】：从晶体形貌、矿物物相和化学成分等角度表征颈椎黄韧带钙化,并结合病理学探讨其病因、形成机制和钙化进程.研究对2例颈椎黄韧带钙化样品进行了显微红外、拉曼、透射电子显微镜(TEM)、扫描电子显微镜(SEM)和同步辐射X射线衍射(XRD)测试,结果表明,钙化物有柱状、粒状、絮状和球状4种形态;柱状和粒状钙化呈单晶体,晶形较好、边界明显,为三斜晶系二羟焦磷酸钙;絮状和球状钙化呈纳米多晶集合体,主要由B型取代的碳羟磷灰石组成.显微红外和拉曼测试显示在钙化集合体中,二羟焦磷酸钙和碳羟磷灰石2种物相分布不均匀,由中央到外围呈现碳羟磷灰石不断减少,二羟焦磷酸钙不断增多的含量变化趋势.通过对钙化物晶体、集合体形貌、物相及不同物相分布关系的分析,本文认为,颈椎黄韧带的钙化初期,首先形成柱状和粒状二羟焦磷酸钙晶体;钙化后期,钙化集合体发生二羟焦磷酸钙的分解和碳羟磷灰石晶体的沉积,前者为后者提供物质来源;碳羟磷灰石沉积过程中,先由纳米级钙化物形成絮状钙化,后形成球状钙化.
[Abstract]:The calcification of cervical ligamentum flavum was characterized by crystal morphology, mineral phase and chemical composition. The etiology, formation mechanism and calcification process of ligamentum flavum were discussed in combination with pathology. Two cases of cervical ligamentum flavum calcification were examined by microinfrared, Raman, transmission electron microscopy (TEM),) scanning electron microscopy (SEM) and synchrotron radiation X-ray diffraction (XRD). The results showed that the calcification was columnar and granular. Flocculent and globular; The columnar and granular calcifications are monocrystalline with good crystal shape and obvious boundary, and the flocculating and globular calcifications are nanocrystalline aggregates, mainly composed of carbon hydroxyapatite substituted by B type. Microscopic infrared and Raman measurements showed that the phase distribution of calcium dihydroxypyrophosphate and carbon-hydroxyapatite was not uniform in calcified aggregates, and the content of calcium dihydroxypyrophosphate was increasing and decreasing from the center to the periphery. Based on the analysis of the distribution of calcified crystals, aggregates, phases and different phases, it is concluded that the columnar and granular calcium dihydroxypyrophosphate crystals were first formed in the early stage of calcification of the ligamentum flavum of the cervical vertebrae. The decomposition of calcium dihydroxypyrophosphate and the deposition of carbon hydroxyapatite crystals occurred in the calcified aggregates in the late period of calcification, the former providing the material source for the latter. In the process of carbon hydroxyapatite deposition, flocculent calcification was first formed by nanometer calcification, then spherical calcification was formed.
【作者单位】： 北京大学地球与空间科学学院矿物环境功能北京市重点实验室造山带与地壳演化教育部重点实验室;北京大学第三医院骨科;
【基金】：国家自然科学基金(批准号:41272048)资助项目
【分类号】：R681.5
，
本文编号：2420872
[Abstract]:The calcification of cervical ligamentum flavum was characterized by crystal morphology, mineral phase and chemical composition. The etiology, formation mechanism and calcification process of ligamentum flavum were discussed in combination with pathology. Two cases of cervical ligamentum flavum calcification were examined by microinfrared, Raman, transmission electron microscopy (TEM),) scanning electron microscopy (SEM) and synchrotron radiation X-ray diffraction (XRD). The results showed that the calcification was columnar and granular. Flocculent and globular; The columnar and granular calcifications are monocrystalline with good crystal shape and obvious boundary, and the flocculating and globular calcifications are nanocrystalline aggregates, mainly composed of carbon hydroxyapatite substituted by B type. Microscopic infrared and Raman measurements showed that the phase distribution of calcium dihydroxypyrophosphate and carbon-hydroxyapatite was not uniform in calcified aggregates, and the content of calcium dihydroxypyrophosphate was increasing and decreasing from the center to the periphery. Based on the analysis of the distribution of calcified crystals, aggregates, phases and different phases, it is concluded that the columnar and granular calcium dihydroxypyrophosphate crystals were first formed in the early stage of calcification of the ligamentum flavum of the cervical vertebrae. The decomposition of calcium dihydroxypyrophosphate and the deposition of carbon hydroxyapatite crystals occurred in the calcified aggregates in the late period of calcification, the former providing the material source for the latter. In the process of carbon hydroxyapatite deposition, flocculent calcification was first formed by nanometer calcification, then spherical calcification was formed.
【作者单位】： 北京大学地球与空间科学学院矿物环境功能北京市重点实验室造山带与地壳演化教育部重点实验室;北京大学第三医院骨科;
【基金】：国家自然科学基金(批准号:41272048)资助项目
【分类号】：R681.5
，
本文编号：2420872
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