大株红景天注射液对三阴性乳腺癌患者生活质量及免疫功能的影响

发布时间：2019-02-13 06:15

【摘要】：目的观察大株红景天注射液联合化疗对三阴性乳腺癌患者免疫功能及生活质量的影响。方法将2014年6月至2016年6月入院的66例三阴性乳腺癌患者随机分成两组,其中观察组和对照组各33例,观察组脱落2例,对照脱落4例,分别完成31例和29例。两组患者选择的化疗方案为TAC方案,观察组在该化疗方案基础上每周期静脉滴注大株红景天注射液10天。治疗2个周期结束时评价临床疗效。结果经过2周期的治疗后,两组患者CD_3~+、CD_4~+、CD_8~+、CD_4~+/CD_8~+、及NK细胞变化明显(P0.05)。且将两组患者治疗后的CD_3~+、CD_4~+、CD_8~+、CD_4~+/CD_8~+及NK细胞值进行比较,差异具有统计学意义(P0.05)。观察组与对照组生活质量改善率分别为58.06%、34.48%,差异具有统计学意义(P0.05)。在不良反应方面,观察组患者心脏毒性及恶心呕吐发生率明显低于对照组,差异具有统计学意义(P0.05)。结论大株红景天注射液改善患者细胞免疫水平,提高患者生活质量,减少化疗过程不良反应的发生。
[Abstract]:Objective to observe the effect of Rhizoma Rhodiola injection combined with chemotherapy on immune function and quality of life (QOL) in triple negative breast cancer patients. Methods 66 patients with three-negative breast cancer admitted from June 2014 to June 2016 were randomly divided into two groups: observation group (n = 33) and control group (n = 33), observation group (n = 2) and control group (n = 4). The chemotherapy regimen of two groups was TAC regimen. On the basis of the chemotherapy regimen, the observation group was treated by intravenous drip of Rhodiola injection for 10 days. Clinical efficacy was evaluated at the end of 2 cycles. Results after 2 cycles of treatment, CD_3~, CD_4~, CD_8~, CD_4~ / CD_8~, and NK cells were significantly changed in both groups (P0.05). The cell values of CD_3~, CD_4~, CD_8~, CD_4~ / CD_8~ and NK were compared between the two groups after treatment (P0.05). The improvement rates of quality of life in the observation group and the control group were 58.06 and 34.48, respectively. The difference was statistically significant (P0.05). The incidence of cardiac toxicity and nausea and vomiting in the observation group was significantly lower than that in the control group (P0.05). Conclusion large strain Rhodiola injection can improve the cellular immunity, improve the quality of life and reduce the adverse reactions during chemotherapy.
【作者单位】：哈励逊国际和平医院;
【基金】：河北省衡水市科学技术研究与发展计划(14022A)
【分类号】：R737.9

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