酪酸梭菌联合抗菌药物对急性阑尾炎患者腹腔镜术后炎症因子及胃肠功能的影响
发布时间：2019-02-25 19:55
【摘要】：目的:探讨酪酸梭菌联合抗菌药物对急性阑尾炎患者腹腔镜术后炎症因子及胃肠功能的影响。方法:选择2014年1月-2015年1月我院拟行腹腔镜手术治疗的急性阑尾炎患者102例,根据入院单双号分为观察组和对照组,各51例。对照组患者术后给予注射用头孢呋辛钠、甲硝唑葡萄糖注射液、头孢克肟分散片抗感染治疗;观察组患者术后在对照组基础上加用酪酸梭菌活菌胶囊1 260 mg,tid,连续服用3 d。比较两组患者术前及术后3 d血清炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)]、胃动素(GAS)、胃泌素(MTL)水平,并记录两组患者胃肠功能恢复时间(肠鸣音出现时间、首次肛门排气时间、术后首次排便时间)及并发症发生情况。结果:术前,两组患者血清炎症因子、GAS、MTL水平比较,差异均无统计学意义(P0.05);术后3 d,两组患者TNF-α、IL-6、CRP水平显著降低,GAS、MTL水平显著升高,且观察组上述指标显著优于对照组,差异均有统计学意义(P0.05)。观察组患者肠鸣音出现时间、首次肛门排气时间、术后首次排便时间均明显短于对照组,差异均有统计学意义(P0.05)。观察组患者并发症发生率为3.92%,显著低于对照组的15.69%,差异有统计学意义(P0.05)。结论:酪酸梭菌联合抗菌药物能有效缓解急性阑尾炎腹腔镜手术患者炎症状态,促进胃肠功能恢复,减少并发症发生。
[Abstract]:Aim: to investigate the effects of Clostridium butyrate combined with antibiotics on inflammatory factors and gastrointestinal function after laparoscopic surgery in patients with acute appendicitis. Methods: 102 patients with acute appendicitis scheduled for laparoscopic surgery from January 2014 to January 2015 were divided into observation group (n = 51) and control group (n = 51). The patients in the control group were treated with cefuroxime sodium, metronidazole glucose injection and cefixime dispersible tablets. The patients in the observation group were treated with Clostridium butyricum capsule 1 260 mg,tid, on the basis of the control group for 3 d. The levels of serum inflammatory factors [tumor necrosis factor 伪 (TNF- 伪), interleukin 6 (IL-6), C reactive protein (CRP), motilin (GAS), gastrin (MTL)] were compared between the two groups before and 3 days after operation. The recovery time of gastrointestinal function (the appearance time of intestinal sound, the first time of anal exhaust, the time of first defecation after operation) and the occurrence of complications were recorded in the two groups. Results: before operation, there was no significant difference in the levels of serum inflammatory factors and GAS,MTL between the two groups (P0.05). On the 3rd day after operation, the levels of TNF- 伪 and IL-6,CRP in the two groups decreased significantly, while the level of GAS,MTL increased significantly, and the above indexes in the observation group were significantly better than those in the control group, the difference was statistically significant (P0.05). The time of bowel sounds, the first anal exhaust time and the first defecation time after operation in the observation group were significantly shorter than those in the control group (P0.05). The incidence of complications in the observation group was 3.92%, which was significantly lower than that in the control group (15.69%) (P0.05). Conclusion: Clostridium butyricum combined with antibiotics can effectively relieve the inflammatory state of patients undergoing laparoscopic appendicitis, promote the recovery of gastrointestinal function, and reduce the incidence of complications.
【作者单位】： 石河子大学医学院第一附属医院胃肠乳腺外科;
【分类号】：R656.8
[Abstract]:Aim: to investigate the effects of Clostridium butyrate combined with antibiotics on inflammatory factors and gastrointestinal function after laparoscopic surgery in patients with acute appendicitis. Methods: 102 patients with acute appendicitis scheduled for laparoscopic surgery from January 2014 to January 2015 were divided into observation group (n = 51) and control group (n = 51). The patients in the control group were treated with cefuroxime sodium, metronidazole glucose injection and cefixime dispersible tablets. The patients in the observation group were treated with Clostridium butyricum capsule 1 260 mg,tid, on the basis of the control group for 3 d. The levels of serum inflammatory factors [tumor necrosis factor 伪 (TNF- 伪), interleukin 6 (IL-6), C reactive protein (CRP), motilin (GAS), gastrin (MTL)] were compared between the two groups before and 3 days after operation. The recovery time of gastrointestinal function (the appearance time of intestinal sound, the first time of anal exhaust, the time of first defecation after operation) and the occurrence of complications were recorded in the two groups. Results: before operation, there was no significant difference in the levels of serum inflammatory factors and GAS,MTL between the two groups (P0.05). On the 3rd day after operation, the levels of TNF- 伪 and IL-6,CRP in the two groups decreased significantly, while the level of GAS,MTL increased significantly, and the above indexes in the observation group were significantly better than those in the control group, the difference was statistically significant (P0.05). The time of bowel sounds, the first anal exhaust time and the first defecation time after operation in the observation group were significantly shorter than those in the control group (P0.05). The incidence of complications in the observation group was 3.92%, which was significantly lower than that in the control group (15.69%) (P0.05). Conclusion: Clostridium butyricum combined with antibiotics can effectively relieve the inflammatory state of patients undergoing laparoscopic appendicitis, promote the recovery of gastrointestinal function, and reduce the incidence of complications.
【作者单位】： 石河子大学医学院第一附属医院胃肠乳腺外科;
【分类号】：R656.8
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