脾切除门奇静脉断流术中鼻腔、静脉给予不同剂量布托啡诺复合丙泊酚的麻醉效果对比观察

发布时间：2019-03-14 18:23

【摘要】：目的比较脾切除门奇静脉断流术中鼻腔、静脉给予不同剂量布托啡诺复合丙泊酚的麻醉效果。方法150例择期行脾切除门奇静脉断流术患者随机分为5组各30例,A组直接以丙泊酚作为诱导剂,在手术过程中保持适当的麻醉深度,根据患者反应追加丙泊酚;B、C组在给予丙泊酚之前,鼻腔给予1、2 mg布托啡诺;D、E组在给予丙泊酚之前,静注1、2 mg布托啡诺。比较各组麻醉效果。结果与A组比较,B、C、D、E组麻醉效果好,患者舒适度、术者满意度高;与D组比较,B组麻醉效果好,患者舒适度、术者满意度高;与E组比较,D组麻醉效果差,患者舒适度、术者满意度低;P均0.05。与同组T0时点比较,各组T2~T5时点MAP、HR降低;与同组T_0、T_1、T_5时点比较,各组T_2~T_4时点SpO_2降低;与A组比较,C、E组T2~T4时点SpO_2降低;与E组比较,C组T2~T4时点SpO_2降低;P均0.05。与A组比较,B、C、D、E组丙泊酚用量少;与D组比较,B组丙泊酚用量少;与E组比较,C组丙泊酚用量少;P均0.05。结论布托啡诺复合丙泊酚用于脾切除门奇静脉断流术麻醉效果较好,相同剂量的布托啡诺经鼻腔给药效果优于静注给药,且高剂量效果优于低剂量。
[Abstract]:Objective to compare the anesthetic effects of different doses of butorphanol combined with propofol on nasal cavity and vein during splenectomy and portal azygos venous devascularization. Methods 150 patients undergoing splenectomy and portal azygos venous devascularization were randomly divided into 5 groups (n = 30). Propofol was used as inducer directly in group A, proper anesthesia depth was maintained in the course of operation, and propofol was added according to the patient's reaction. Group B, C received 1, 2 mg butorphanol intranasally before propofol was given, and group E received 1, 2 mg butorphanol intravenously before propofol was given. The anesthetic effect of each group was compared. Results compared with group A, group B, C, D, group E had better anesthetic effect, patient comfort and satisfactory degree of operation, compared with group D, group B had better anesthetic effect, patient comfort and satisfactory degree of operation. Compared with group E, the anesthetic effect of group D was poor, the patient comfort and the satisfaction degree of the patients were lower than that of group E (P < 0.05). Compared with the same group at T0, MAP,HR at T2~T5, SpO_2 at T_2~T_4, SpO_2 at T2~T4, and SpO_2 at T2~T4 in group E were lower than those in group T0, T1 and 5 in each group, and that in group C and E were significantly lower than those in group A (P < 0.01), and in group C (P < 0.01) and in group C (P < 0.05), respectively. Compared with E group, the time point SpO_2 of T2~T4 in group C was significantly lower than that in group E (P < 0.05). Compared with group A, group B, C, D, the dosage of propofol in group E was lower than that in group D, the dosage of propofol in group B was lower than that in group E, and the dosage of propofol in group C was lower than that in group E (P < 0.05). Conclusion the anesthetic effect of butorphanol combined with propofol in splenectomy and portal azygos venous devascularization is better. The same dose of butorphanol is better than intravenous administration, and the effect of high dose is better than that of low dose.
【作者单位】：齐齐哈尔医学院附属第一医院;
【分类号】：R614

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