疏肝健脾补肾方加减对三阴乳腺癌术后复发转移及免疫功能的影响

发布时间：2019-03-18 10:35

【摘要】：目的:观察疏肝健脾补肾方加减对三阴乳腺癌术后患者复发转移及免疫功能的影响。方法:病例来源于我院2008年1月~2012年5月诊治的三阴乳腺癌术后患者40例,随机分为2组,每组20例。两组均完成术后辅助化疗或化放疗,在此基础上,治疗组加用疏肝健脾补肾方加减治疗,每日1剂,3月为1个疗程,前半年连服2疗程,之后1年服用3个疗程,共服1.5年,如复发转移则停服,定期随诊复查;对照组则是单纯定期随诊复查。观察终点为复发转移。连续随访3年,比较两组术后复发转移情况,并观察对免疫功能的影响。结果:与对照组相比,治疗组术后复发转移率降低(P0.05);治疗组CD~3、CD~4、CD~4/CD~8、NK上升,CD~8下降,均具有统计学意义(P0.05)。结论:疏肝健脾补肾方加减降低了三阴乳腺癌术后复发转移率,调节了免疫功能,在一定程度上提高了患者的生活质量,值得临床推广运用。
[Abstract]:Objective: to observe the effect of Shugan Jianpi Bushen recipe on recurrence, metastasis and immune function of patients with triple-negative breast cancer after operation. Methods: from January 2008 to May 2012, 40 patients with triple-negative breast cancer were randomly divided into two groups with 20 cases in each group. Both groups completed postoperative adjuvant chemotherapy or chemoradiotherapy. On the basis of this, the treatment group was added with Shugan Jianpi Bushen recipe plus subtractive treatment, 1 dose per day, 3 months as a course of treatment, 2 consecutive courses of treatment in the first half of the year, and 3 courses of treatment in the next year. A total of 1.5 years, if recurrence and metastasis will stop taking, regular follow-up; The control group was followed up on a regular basis. The end point of observation was recurrence and metastasis. After 3 years of follow-up, the recurrence and metastasis of the two groups were compared, and the effect on immune function was observed. Results: compared with the control group, the recurrence and metastasis rate of the treatment group decreased (P0.05), the CD~3,CD~4,CD~4/CD~8,NK of the treatment group increased and the CD~8 of the treatment group decreased, all had statistical significance (P0.05). Conclusion: the prescription of soothing liver and invigorating spleen and tonifying kidney can reduce the recurrence and metastasis rate of triple-negative breast cancer, regulate the immune function, and improve the quality of life of patients to a certain extent. It is worth popularizing and applying in clinical practice.
【作者单位】：秦皇岛市第四医院肿瘤内科;秦皇岛第四医院中西医结合科;
【基金】：秦皇岛市科学技术研究与发展计划项目—中医药对三阴乳腺癌术后预防复发转移的对比性研究(项目编号:201502A156)
【分类号】：R737.9

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