脉冲冲洗术治疗对急性骨与软组织感染患者炎性介质因子水平的影响

发布时间：2019-03-21 17:07

【摘要】：目的分析脉冲冲洗术对急性骨与软组织感染患者炎性介质因子表达的影响及临床意义。方法选取2011年5月-2016年5月218例骨与软组织感染患者为研究对象,按照清除创面感染方式的不同,分为传统组107例,以凡士林纱布覆盖的方式进行抗感染处理;研究组111例,以脉冲冲洗术进行清创处理,比较两组患者炎性应激因子超敏C-反应蛋白(hs-CRP)、肿瘤细胞因子-α(TNF-α)、干扰素-γ(IFN-γ)、血沉(ESR)与其他炎性因子白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-8(IL-8)、白介素-10(IL-10)表达的变化及创面正常愈合效果的比较。结果研究组炎性应激指标hs-CRP(2.31±0.56)pg/ml、IFN-γ(22.57±3.76)pg/ml、ESR(13.67±3.82)mm/h表达比传统组下降明显,差异有统计学意义(P0.05),TNF-α(38.57±2.76)pg/ml表达比传统组显著上升,差异有统计学意义(P0.05);研究组其他炎性因子IL-1β(3.21±0.83)pg/ml、IL-6(78.82±12.84)pg/ml、IL-8(81.46±13.76)pg/ml、IL-10(4.67±2.92)pg/ml表达均较传统组显著下降,差异有统计学意义(P0.05)。结论脉冲冲洗术在急性骨与软组织感染中具有良好的抗菌消炎作用,可明显改善患者炎性应激因子与其他炎性因子的表达水平,是一种操作性较高的、对治疗感染有积极意义的临床术式。
[Abstract]:Objective to analyze the effect and clinical significance of pulse washing on the expression of inflammatory mediators in patients with acute bone and soft tissue infection. Methods 218 patients with bone and soft tissue infection were selected from May 2011 to May 2016. According to the different ways of clearing the wound, 107 patients in the traditional group were treated with vaseline gauze. The inflammatory stress factor hypersensitive C-reactive protein (hs-CRP), tumor cytokine-伪 (TNF- 伪) and interferon-纬 (IFN- 纬) were compared between the two groups. The changes of expression of IL-1 尾, IL-6, IL-8, IL-10 in erythrocyte sedimentation rate (ESR) and other inflammatory factors (IL-1 尾, IL-6, IL-8, IL-10) and the effect of normal wound healing were compared. Results the expression of inflammatory stress index hs-CRP (2.31 卤0.56) pg/ml,IFN- 纬 (22.57 卤3.76) pg/ml,ESR (13.67 卤3.82) mm/h in the study group was significantly lower than that in the traditional group (P0.05). The expression of TNF- 伪 (38.57 卤2.76) pg/ml was significantly higher than that of the traditional group (P0.05). The expression of other inflammatory factors, IL-1 尾 (3.21 卤0.83) pg/ml,IL-6 (78.82 卤12.84) pg/ml,IL-8, (81.46 卤13.76) pg/ml,IL-10, (4.67 卤2.92) pg/ml in the study group was significantly lower than that in the traditional group. The difference was statistically significant (P0.05). Conclusion Pulsed washing has a good antibacterial and anti-inflammatory effect in acute bone and soft tissue infection and can significantly improve the expression level of inflammatory stress factors and other inflammatory factors in patients with acute bone and soft tissue infection. A clinical procedure that has a positive effect on the treatment of infection.
【作者单位】：河南省洛阳正骨医院河南省骨科医院风湿病科;河南省洛阳正骨医院河南省骨科医院运动医学科;河南省洛阳正骨医院河南省骨科医院髋部损伤一科;河南省洛阳正骨医院河南省骨科医院脊柱外三科;河南省洛阳正骨医院河南省骨科医院膝部损伤二科;
【分类号】：R63

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