氨甲环酸对强直性脊柱炎初次全髋关节置换失血量影响的研究

发布时间：2019-04-15 14:46

【摘要】：[目的]比较氨甲环酸对强直性脊柱炎初次全髋关节置换失血量的影响。[方法]2009年1月到2014年12月收治90例强直性脊柱炎患者,均行单侧置换,病人随机分为3组,对照组不应用氨甲环酸,静脉应用组术前10 min给予氨甲环酸15 mg/kg加入100 ml生理盐水静滴,局部应用组关闭切口前倒入氨甲环酸2 g,比较三组的围手术期的总失血量、术中失血量、引流量、隐性失血量、输血率、输血反应、手术并发症、血红蛋白变化、深静脉血栓发生率。[结果]对照组、静脉应用组和静脉应用组总失血量、引流量和隐性失血量经方差分析,P0.001,差异有统计学意义,而不同用药方式之间无明显区别。术中出血量无明显区别。术后血红蛋白的下降三组之间无明显区别,输血率三组均为100%。三组深静脉血栓发生率为0,对照组的肌肉间静脉形成发生2例,静脉应用组和局部应用组各发生3例。[结论]强直性脊柱炎患者行全髋关节置换术,应用氨甲环酸可减少围手术期出血,但不同用药方式无明显区别。
[Abstract]:[objective] to compare the effect of carbacycloic acid on blood loss after primary total hip arthroplasty in patients with ankylosing spondylitis (ankylosing spondylitis). [methods] from January 2009 to December 2014, 90 patients with ankylosing spondylitis were treated with unilateral replacement. The intravenous application group received 15 mg/kg carbacycloic acid plus 100 ml saline intravenous drip at 10 min before the operation, and the local application group received 2 g carbacycloic acid before closing the incision. The total blood loss, intraoperative blood loss and drainage volume were compared among the three groups during the perioperative period, and the intraoperative bleeding volume and drainage volume were compared among the three groups. Recessive blood loss, blood transfusion rate, blood transfusion reaction, operative complications, hemoglobin changes, incidence of deep venous thrombosis. [results] the total blood loss, drainage volume and recessive blood loss in the control group, intravenous application group and intravenous application group were analyzed by variance analysis (P0.001), but there was no significant difference among different drug use methods. There was no significant difference in the volume of bleeding during the operation. There was no significant difference in the decrease of hemoglobin among the three groups, and the blood transfusion rate was 100% in the three groups. The incidence of deep venous thrombosis was 0 in the three groups, 2 cases in the control group, 3 cases in the intravenous application group and 3 cases in the local application group. [conclusion] the patients with ankylosing spondylitis underwent total hip arthroplasty, and the use of carbacycloic acid could reduce the perioperative bleeding, but there was no significant difference among different treatment methods.
【作者单位】：滕州市工人医院骨科;
【分类号】：R687.4

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