肛周脓肿患者病原菌及其对抗菌药物的耐药性分析

发布时间：2019-04-18 12:22

【摘要】：目的:通过对肛周脓肿患者感染的病原菌的耐药性研究,为临床合理应用抗生素的提供依据。方法:分析2013年1月至2014年6月肛周脓肿感染患者的病原菌特点,应用纸片扩散法(K-B)检测肛周脓肿患者病原菌对抗菌药物的耐药性;双纸片扩散确诊试验检测超广谱β-内酰胺酶(Extended Spectrum Beta-Lactamases ESBLs)。结果:从300例肛周脓肿患者标本细菌培养阳性262例,阳性率87.30%,共分离出322株病原菌,其中革兰阴性菌234株,占72.67%,革兰阳性菌88株,占27.33%,混合感染占22.90%。检出的322株病原菌中,对阿莫西林/棒酸、哌拉西林/他唑巴坦、替卡西林/棒酸、头孢哌酮/舒巴坦、亚胺培南、美罗培南、阿米卡星的耐药率普遍较低。检出病原菌中产ESBLs 98株,占30.43%。结论:肛周脓肿感染仍是以革兰阴性菌为主,部分患者为混合感染,病原菌对大多数抗菌药物的耐药性较高,且病原菌产ESBLs率较高,故合理应用抗生素尤为重要。
[Abstract]:Objective: to study the drug resistance of pathogenic bacteria in patients with perianal abscess and to provide evidence for the rational use of antibiotics in clinic. Methods: the characteristics of pathogenic bacteria in patients with perianal abscess infection from January 2013 to June 2014 were analyzed, and the antimicrobial resistance of pathogenic bacteria in patients with perianal abscess was detected by disk diffusion method. Detection of extended-spectrum 尾-lactamase (Extended Spectrum Beta-Lactamases ESBLs). By double disk diffusion diagnosis test Results: 262 cases (87.30%) were positive in bacterial culture from 300 patients with perianal abscess. A total of 322 strains of pathogenic bacteria were isolated. Among them, 234 strains were gram-negative bacteria (72.67%), 88 strains were gram-positive bacteria (27.33%), and 88 strains were Gram-positive bacteria (27.33%). Mixed infection accounted for 22.90%. The resistance rates to amoxicillin / clavulanic acid, piperacillin / tazobactam, teicacillin / clavic acid, cefoperazone / sulbactam, imipenem, meropenem and amikacin were generally low in 322 isolates. 98 strains of ESBLs were detected, accounting for 30.43%. Conclusion: the infection of perianal abscess is still dominated by Gram-negative bacteria, and some of the patients are mixed infection. The pathogen is more resistant to most antibiotics, and the rate of ESBLs production by pathogenic bacteria is higher, so it is very important to use antibiotics rationally.
【作者单位】：承德医学院附属医院;河北省宽城满族自治县孟子岭乡卫生院;河北省宽城满族自治县宽城中心卫生院;
【基金】：河北省承德市科技支撑计划项目,(编号:201422032)
【分类号】：R657.15

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