骨氏葆方联合膝关节内粘疗法对肾虚血瘀型膝重度骨关节炎关节功能的影响及临床有效性评价研究
发布时间：2019-04-19 07:24
【摘要】：目的:研究分析骨氏葆方与膝关节内粘疗法联合治疗对肾虚血瘀型膝重度骨关节炎功能的治疗效果与安全性。方法:肾虚血瘀型膝重度关节炎患者100例,按照随机数字表法将其分为治疗组和对照组各50例,两组患者均给予膝关节内粘疗法和健康教育等基础治疗,在此基础上给予对照组患者口服盐酸氨基葡萄糖胶囊进行治疗,给予治疗组患者骨氏葆方进行治疗,连续治疗5周后观察比较两组患者的治疗效果,并应用中医症状评分标准对两组患者的临床症状进行评分,同时监测两组患者在治疗前后的骨型碱性磷酸酶、降钙素和血沉的变化状况。结果:治疗后两组患者的血沉均显著降低(P0.01),且治疗组患者的降低程度显著优于对照组(P0.05),差异有统计学意义。但两组患者的降钙素和骨型碱性磷酸酶均无改善,其差异无统计学意义(P0.05)。治疗后两组患者的主要症状和体征积分均显著降低(P0.05),且治疗组患者的改善程度显著优于对照组(P0.01),其差异有统计学意义。治疗后两组患者的WOMAC评分、ISOA评分和疼痛评分均显著降低(P0.01),但治疗组患者的降低程度显著优于对照组(P0.01),其差异有统计学意义。治疗组患者的总有效率(98.00%)显著优于对照组(82.00%),说明治疗组患者的临床疗效显著优于对照组,差异有统计学意义(P0.05)。结论:骨氏葆方与膝关节内粘疗法联合应用能够有效改善患者的临床体征,降低患者血沉,是临床上治疗肾虚血瘀型膝重度关节炎的有效方案。
[Abstract]:Aim: to study the efficacy and safety of GuShi Bao recipe combined with intra-articular viscosity therapy in the treatment of severe osteoarthritis of the knee with kidney deficiency and blood stasis. Methods: 100 patients with severe arthritis of knee due to kidney deficiency and blood stasis were randomly divided into two groups: treatment group (n = 50) and control group (n = 50). On this basis, the patients in the control group were treated with oral glucosamine hydrochloride capsules, and the patients in the treatment group were treated with Gu Shi Bao Fang. After 5 weeks of continuous treatment, the therapeutic effects of the two groups were observed and compared. The clinical symptoms of the two groups were evaluated by TCM symptom scoring standard, and the changes of bone alkaline phosphatase, calcitonin and erythrocyte sedimentation rate (ESR) were monitored before and after treatment. Results: after treatment, the ESR of the two groups decreased significantly (P0.01), and the degree of decrease of the treatment group was significantly better than that of the control group (P0.05), the difference was statistically significant. There was no significant difference in calcitonin and bone alkaline phosphatase between the two groups (P0.05). After treatment, the scores of main symptoms and signs of the two groups were significantly decreased (P0.05), and the improvement of the treatment group was significantly better than that of the control group (P0.01), the difference was statistically significant. After treatment, the WOMAC score, ISOA score and pain score of the two groups were significantly decreased (P0.01), but the degree of decrease in the treatment group was significantly better than that in the control group (P0.01), and the difference was statistically significant. The total effective rate of the treatment group (98.00%) was significantly better than that of the control group (82.00%), indicating that the clinical efficacy of the treatment group was significantly better than that of the control group, the difference was statistically significant (P0.05). Conclusion: the combined application of Gu Shi Bao Fang and knee joint internal viscosity therapy can effectively improve the clinical signs of the patients and reduce the ESR of the patients. It is an effective scheme for the treatment of severe arthritis of the knee with kidney deficiency and blood stasis.
【作者单位】： 河北省中医院骨伤二科;
【基金】：河北省中医药管理局项目(2016166)
【分类号】：R684.3
，
本文编号：2460738
[Abstract]:Aim: to study the efficacy and safety of GuShi Bao recipe combined with intra-articular viscosity therapy in the treatment of severe osteoarthritis of the knee with kidney deficiency and blood stasis. Methods: 100 patients with severe arthritis of knee due to kidney deficiency and blood stasis were randomly divided into two groups: treatment group (n = 50) and control group (n = 50). On this basis, the patients in the control group were treated with oral glucosamine hydrochloride capsules, and the patients in the treatment group were treated with Gu Shi Bao Fang. After 5 weeks of continuous treatment, the therapeutic effects of the two groups were observed and compared. The clinical symptoms of the two groups were evaluated by TCM symptom scoring standard, and the changes of bone alkaline phosphatase, calcitonin and erythrocyte sedimentation rate (ESR) were monitored before and after treatment. Results: after treatment, the ESR of the two groups decreased significantly (P0.01), and the degree of decrease of the treatment group was significantly better than that of the control group (P0.05), the difference was statistically significant. There was no significant difference in calcitonin and bone alkaline phosphatase between the two groups (P0.05). After treatment, the scores of main symptoms and signs of the two groups were significantly decreased (P0.05), and the improvement of the treatment group was significantly better than that of the control group (P0.01), the difference was statistically significant. After treatment, the WOMAC score, ISOA score and pain score of the two groups were significantly decreased (P0.01), but the degree of decrease in the treatment group was significantly better than that in the control group (P0.01), and the difference was statistically significant. The total effective rate of the treatment group (98.00%) was significantly better than that of the control group (82.00%), indicating that the clinical efficacy of the treatment group was significantly better than that of the control group, the difference was statistically significant (P0.05). Conclusion: the combined application of Gu Shi Bao Fang and knee joint internal viscosity therapy can effectively improve the clinical signs of the patients and reduce the ESR of the patients. It is an effective scheme for the treatment of severe arthritis of the knee with kidney deficiency and blood stasis.
【作者单位】： 河北省中医院骨伤二科;
【基金】：河北省中医药管理局项目(2016166)
【分类号】：R684.3
，
本文编号：2460738
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